The role of DNA damage repair (DDR) system in response to immune checkpoint inhibitor (ICI) therapy

C Shi, K Qin, A Lin, A Jiang, Q Cheng, Z Liu… - Journal of Experimental …, 2022 - Springer
As our understanding of the mechanisms of cancer treatment has increased, a growing
number of studies demonstrate pathways through which DNA damage repair (DDR) affects …

Anticancer potential of phytochemicals derived from mangrove plants: Comprehensive mechanistic insights

R Chowdhury, MS Bhuia, MS Al Hasan… - Food Science & …, 2024 - Wiley Online Library
Cancer is a collection of illnesses characterized by aberrant cellular proliferation that can
infiltrate or metastasize to distant anatomical sites, posing a notable threat to human well …

Apigeninidin-enriched Sorghum bicolor (L. Moench) extracts alleviate Aflatoxin B1-induced dysregulation of male rat hypothalamic-reproductive axis

SE Owumi, MT Otunla, UO Arunsi… - … Biology and Medicine, 2022 - journals.sagepub.com
We examined the protective effect of the apigeninidin (API)-enriched fraction from Sorghum
bicolor sheaths extracts (SBE-05, SBE-06, and SBE-07) against aflatoxin B1 (AFB1)-induced …

Bacterial immunotherapy: is it a weapon in our arsenal in the fight against cancer?

S Sharma, H Sharma, H Gogoi - Frontiers in Immunology, 2023 - frontiersin.org
Advances in understanding the genetic basis of cancer have driven alternative treatment
approaches. Recent findings have demonstrated the potential of bacteria and it's …

[HTML][HTML] Therapeutic strategies to enhance Tumor Antigenicity: making the Tumor detectable by the Immune System

D Meraviglia-Crivelli, A Zheleva, M Barainka, B Moreno… - Biomedicines, 2022 - mdpi.com
Cancer immunotherapy has revolutionized the oncology field, but many patients still do not
respond to current immunotherapy approaches. One of the main challenges in broadening …

Sodium‐Glucose Co‐Transporter‐2 Inhibitor Empagliflozin Attenuates Sorafenib‐Induced Myocardial Inflammation and Toxicity

CH Liu, YC Ho, WC Lee, CY Huang… - Environmental …, 2024 - Wiley Online Library
Environmental antineoplastics such as sorafenib may pose a risk to humans through water
recycling, and the increased risk of cardiotoxicity is a clinical issue in sorafenib users. Thus …

Genes and the environment in cancer: focus on environmentally induced DNA methylation changes

F Coppedè - Cancers, 2023 - mdpi.com
Cancer has traditionally been viewed as a genetic disorder resulting from the accumulation
of gene mutations, chromosomal rearrangements, and aneuploidies in somatic cells …

Exploring the Role of Clustered Mutations in Carcinogenesis and Their Potential Clinical Implications in Cancer

Y Li, R Zhu, J **, H Guo, J Zhang, Z He… - International Journal of …, 2024 - mdpi.com
Abnormal cell proliferation and growth leading to cancer primarily result from cumulative
genome mutations. Single gene mutations alone do not fully explain cancer onset and …

Multi-Endpoint Toxicological Assessment of Chrysin Loaded Oil-in-Water Emulsion System in Different Biological Models

P Pitchakarn, P Ting, P Buacheen, J Karinchai… - Nanomaterials, 2024 - mdpi.com
Chrysin is hypothesized to possess the ability to prevent different illnesses, such as
diabetes, cancer, and neurodegenerative disorders. Nonetheless, chrysin has a low …

Molecular dynamics of DNA repair and carcinogen interaction: Implications for cancer initiation, progression, and therapeutic strategies

E Alyafeai, E Qaed, HS Al-Mashriqi… - Mutation Research …, 2024 - Elsevier
The integrity of the genetic material in human cells is continuously challenged by
environmental agents and endogenous stresses. Among these, environmental carcinogens …