Genetic variation associated with disease often appears in non-coding parts of the genome.
Understanding the mechanisms by which this phenomenon leads to disease is necessary to …

Mammalian retinal degenerations initiated by gene defects in rods, cones or the retinal
pigmented epithelium (RPE) often trigger loss of the sensory retina, effectively leaving the …

CTCF and the associated cohesin complex play a central role in insulator function and
higher-order chromatin organization of mammalian genomes. Recent studies identified a …

In the past century, nearly all of the biological sciences have been directly affected by
discoveries and developments in genetics, a fast-evolving subject with important theoretical …

Background Maternal care is associated with long-term effects on behavior and epigenetic
programming of the NR3C1 (GLUCOCORTICOID RECEPTOR) gene in the hippocampus of …

Protocadherins (Pcdhs) are cell adhesion molecules that belong to the cadherin
superfamily, and are subdivided into clustered (cPcdhs) and non-clustered Pcdhs (ncPcdhs) …

Early life experience is associated with long-term effects on behavior and epigenetic
programming of the NR3C1 (GLUCOCORTICOID RECEPTOR) gene in the hippocampus of …

Cadherins are Ca2+-dependent cell-cell adhesion molecules that play critical roles in
animal morphogenesis. Various cadherin-related molecules have also been identified …

Stochastic activation of clustered Protocadherin (Pcdh) α, β, and γ genes generates a cell-
surface identity code in individual neurons that functions in neural circuit assembly. Here, we …

The closely linked human protocadherin (Pcdh) α, β, and γ gene clusters encode 53 distinct
protein isoforms, which are expressed in a combinatorial manner to generate enormous …