Segmentation is a fundamental feature of the vertebrate body plan. This metameric
organization is first implemented by somitogenesis in the early embryo, when paired …

Segmentation of the paraxial mesoderm is a major event of vertebrate development that
establishes the metameric patterning of the body axis. This process involves the periodic …

The theory of retrograde menstruation as aetiopathogenesis of endometriosis formulated by
John Sampson in 1927 shows clear shortcomings: this does not explain why retrograde …

The segmentation clock is an oscillating genetic network thought to govern the rhythmic and
sequential subdivision of the elongating body axis of the vertebrate embryo into somites: the …

In this essay I will sketch some ideas for how to think about models in biology. I will begin by
trying to dispel the myth that quantitative modeling is somehow foreign to biology. I will then …

One of the most striking features of the human vertebral column is its periodic organization
along the anterior-posterior axis. This pattern is established when segments of vertebrates …

Despite their overwhelming complexity, living cells display a high degree of internal
mechanical and functional organization which can largely be attributed to the intracellular …

In vertebrate embryos, somites, the precursor of vertebrae, form from the presomitic
mesoderm (PSM), which is composed of cells displaying signaling oscillations. Cellular …

Proper vertebrae formation relies on a tissue-wide oscillator called the segmentation clock.
Individual cellular oscillators in the presomitic mesoderm are modulated by intercellular …

Periodic somite segmentation is controlled by the cyclic gene Hes7, whose oscillatory
expression depends upon negative feedback with a delayed timing. The mechanism that …