There are approximately 800 annotated G protein–coupled receptor (GPCR) genes, making
these membrane receptors members of the most abundant gene family in the human …

The enteric nervous system (ENS) provides the intrinsic innervation of the bowel and is the
most neurochemically diverse branch of the peripheral nervous system, consisting of two …

Background: Clinical data indicate that estrogen receptor–positive/progesterone receptor–
negative (ER+/PR−) breast cancers are less sensitive to tamoxifen than are ER+/PR+ …

G-protein-coupled receptors (GPCR) are involved in directly and indirectly controlling an
extraordinary variety of physiological functions. Their key roles in cellular communication …

For decades, it has been generally proposed that a given receptor always interacts with a
particular GTP-binding protein (G-protein) or with multiple G-proteins within one family …

All physiological events in living organisms originated as specific chemical/biochemical
signals on the cell surface and transmitted into the cytoplasm. This signal is translated within …

Abstract “Molecular Glues” are defined as small molecules that can either be endogenous or
synthetic which promote interactions between proteins at their interface. Allosteric …

Since the discovery of the first rhodopsin mutation that causes retinitis pigmentosa in 1990,
significant progresses have been made in elucidating the pathophysiology of diseases …

The endothelin system is a vertebrate-specific innovation with important roles in regulating
the cardiovascular system and renal and pulmonary processes, as well as the development …

Background Hirschsprung's disease (HSCR) is one the most common congenital intestinal
disease. It leads to aganglionic megacolon in the early childhood. Several susceptibility …