Formation and function of multiciliated cells

Q Lyu, Q Li, J Zhou, H Zhao - Journal of Cell Biology, 2024 - rupress.org
In vertebrates, multiciliated cells (MCCs) are terminally differentiated cells that line the
airway tracts, brain ventricles, and reproductive ducts. Each MCC contains dozens to …

The multifaceted roles of microtubule-associated proteins in the primary cilium and ciliopathies

J Deretic, E Odabasi… - Journal of Cell …, 2023 - journals.biologists.com
The primary cilium is a conserved microtubule-based organelle that is critical for transducing
developmental, sensory and homeostatic signaling pathways. It comprises an axoneme with …

EHD1 promotes CP110 ubiquitination by centriolar satellite delivery of HERC2 to the mother centriole

S **e, N Naslavsky, S Caplan - EMBO reports, 2023 - embopress.org
Primary cilia are sensory organelles that coordinate diverse signaling pathways, controlling
development and homeostasis. Progression beyond the early steps of ciliogenesis requires …

Regulation of epidermal stratification and development by basal keratinocytes

H Yin, M Hu, D Li - Journal of cellular physiology, 2023 - Wiley Online Library
The epidermis is a stratified squamous epithelium distributed in the outermost layer of the
skin and is intimately involved in the formation of a physical barrier to pathogens. Basal …

[HTML][HTML] Peripheral and central control of obesity by primary cilia

Y Wu, J Zhou, Y Yang - Journal of Genetics and Genomics, 2023 - Elsevier
Primary cilia are hair-like structures that protrude from the cell surface. They are capable of
sensing external cues and conveying a vast array of signals into cells to regulate a variety of …

Emerging insights into CP110 removal during early steps of ciliogenesis

S **e, N Naslavsky, S Caplan - Journal of cell science, 2024 - journals.biologists.com
The primary cilium is an antenna-like projection from the plasma membrane that serves as a
sensor of the extracellular environment and a crucial signaling hub. Primary cilia are …

Cytoskeletal networks in primary cilia: Current knowledge and perspectives

R Ge, M Cao, M Chen, M Liu… - Journal of Cellular …, 2022 - Wiley Online Library
Primary cilia, microtubule‐based protrusions present on the surface of most mammalian
cells, function as sensory organelles that monitor extracellular signals and transduce them …

CYLD Maintains Retinal Homeostasis by Deubiquitinating ENKD1 and Promoting the Phagocytosis of Photoreceptor Outer Segments

S Yang, F Yu, M Yang, H Ni, W Bu, H Yin… - Advanced …, 2024 - Wiley Online Library
Phagocytosis of shed photoreceptor outer segments by the retinal pigment epithelium (RPE)
is essential for retinal homeostasis. Dysregulation of the phagocytotic process is associated …

Primary cilium‐mediated signaling cascade suppresses age‐related biliary fibrosis

R Hong, X Tian, H Ma, H Ni, J Yang… - Journal of Cellular …, 2023 - Wiley Online Library
The primary cilium is increasingly recognized as a crucial player in the physiology of biliary
epithelial cells (BECs). However, the precise role of primary cilia in the development of age …

Melanocortin 1 receptor mediates melanin production by interacting with the BBSome in primary cilia

X Tian, H Wang, S Liu, W Liu, K Zhang, X Gao, Q Li… - PLoS …, 2024 - journals.plos.org
Production of melanin pigments is a protective mechanism of the skin against ultraviolet
(UV)-induced damage and carcinogenesis. However, the molecular basis for …