Currently available evidence supports a role for the hepatitis B virus (HBV) x gene and
protein in the pathogenesis of HBV‐induced hepatocellular carcinoma (HCC). HBx gene is …

To replicate their genomes in cells and generate new progeny, viruses typically require
factors provided by the cells that they have infected. Subversion of the cellular machinery …

Epigenetic modification can mediate environmental influences on gene expression and can
modulate the disease risk associated with genetic variation. Epigenetic analysis therefore …

Hepatocellular carcinoma (HCC) is one of the leading causes of death induced by cancer in
the modern world and majority of the cases are related to chronic hepatitis B virus (HBV) …

Hepatocellular carcinoma (HCC) is the sixth most common cancer in the world and is
usually caused by viral hepatitis (HBV and HCV), alcoholic, and non-alcoholic fatty liver …

The liver acts as a hub for metabolic reactions to keep a homeostatic balance during
development and growth. The process of liver cancer development, although poorly …

Background Recent studies have shown that toll-like receptor 4 (TLR4) is involved in
hepatocarcinogenesis. However, the significance of TLR4 signaling in cancer development …

Liver cancer is one of the most frequent solid cancers that kills more than 650,000 people
around the world each year. Though great improvements have been done in last 10 years …

Reactive oxygen species (ROS) can cause severe damage to DNA, proteins and lipids in
normal cells, contributing to carcinogenesis and various pathological conditions. While …

Hepatitis B virus (HBV) and hepatitis C virus (HCV) infection were known to be risk factors
for HCC, they were suspected to promote its development by eliciting epigenetic changes …