Astrocytes contribute to the complex cellular pathology of Alzheimer's disease (AD).
Neurons and astrocytes function in close collaboration through neurotransmitter recycling …

Synapse loss and damage are central features of Alzheimer's disease (AD) and contribute to
the onset and progression of its behavioural and physiological features. Here we review the …

Our incomplete understanding of the link between Alzheimer's Disease pathology and
symptomatology is a crucial obstacle for therapeutic success. Recently, translational studies …

Synaptic disturbances in excitatory to inhibitory (E/I) balance in forebrain circuits are thought
to contribute to the progression of Alzheimer's disease (AD) and dementia, although direct …

The science of large-scale brain networks offers a powerful paradigm for investigating
cognitive and affective dysfunction in psychiatric and neurological disorders. This review …

Objective To propose a new hypothesis that GABAergic dysfunction in excitatory and
inhibitory (E/I) imbalance drives the pathogenesis of Alzheimer's disease (AD). Background …

Neuronal network dysfunction is increasingly recognized as an early symptom in
Alzheimer's disease (AD) and may provide new entry points for diagnosis and intervention …

Alzheimer's disease (AD) is characterized pathologically by the deposition of β-amyloid
peptides (Aβ) and the accumulation of neurofibrillary tangles (NFTs) composed of hyper …

A growing body of evidence has demonstrated a link between Alzheimer disease (AD) and
epilepsy. Late-onset epilepsy and epileptiform activity can precede cognitive deterioration in …

Identifying effective treatments for Alzheimer's disease (AD) has proven challenging and has
instigated a shift in AD research focus toward the earliest disease-initiating cellular …