Contemporary mouse genetic reference populations are a powerful platform to discover
complex disease mechanisms. Advanced high-diversity mouse populations include the …

The mouse is the most extensively used mammalian model for biomedical and aging
research, and an extensive catalogue of laboratory resources is available to support …

Although it is well accepted that air pollution exposure exacerbates preexisting airway
disease, it has not been firmly established that long-term pollution exposure increases the …

The laboratory mouse is the workhorse of immunology, used as a model of mammalian
immune function, but how well immune responses of laboratory mice reflect those of free …

Abstract The Collaborative Cross Consortium reports here on the development of a unique
genetic resource population. The Collaborative Cross (CC) is a multiparental recombinant …

The Collaborative Cross (CC) is a mouse recombinant inbred strain panel that is being
developed as a resource for mammalian systems genetics. Here we describe an experiment …

Genetic variation drives phenotypic diversity and influences the predisposition to metabolic
disease. Here, we characterize the metabolic phenotypes of eight genetically distinct inbred …

Existing mouse models of lethal Ebola virus infection do not reproduce hallmark symptoms
of Ebola hemorrhagic fever, neither delayed blood coagulation and disseminated …

The mammalian gut microbiota is considered to be determined mostly by diet, while the
effect of genotype is still controversial. Here, we examined the effect of genotype on the gut …

The mammalian gut harbors complex and variable microbial communities, across both host
phylogenetic space and conspecific individuals. A synergy of host genetic and …