[HTML][HTML] Cell fate decisions, transcription factors and signaling during early retinal development
The development of the vertebrate eyes is a complex process starting from anterior-posterior
and dorso-ventral patterning of the anterior neural tube, resulting in the formation of the eye …
and dorso-ventral patterning of the anterior neural tube, resulting in the formation of the eye …
Connecting the retina to the brain
The visual system is beautifully crafted to transmit information of the external world to visual
processing and cognitive centers in the brain. For visual information to be relayed to the …
processing and cognitive centers in the brain. For visual information to be relayed to the …
[HTML][HTML] Cytoneme signaling provides essential contributions to mammalian tissue patterning
During development, morphogens pattern tissues by instructing cell fate across long
distances. Directly visualizing morphogen transport in situ has been inaccessible, so the …
distances. Directly visualizing morphogen transport in situ has been inaccessible, so the …
Cytoneme delivery of Sonic Hedgehog from ligand-producing cells requires Myosin 10 and a Dispatched-BOC/CDON co-receptor complex
Morphogens function in concentration-dependent manners to instruct cell fate during tissue
patterning. The cytoneme morphogen transport model posits that specialized filopodia …
patterning. The cytoneme morphogen transport model posits that specialized filopodia …
Hedgehog pathway activation requires coreceptor-catalyzed, lipid-dependent relay of the Sonic Hedgehog ligand
BM Wierbowski, K Petrov, L Aravena, G Gu, Y Xu… - Developmental cell, 2020 - cell.com
Hedgehog signaling governs critical processes in embryogenesis, adult stem cell
maintenance, and tumorigenesis. The activating ligand, Sonic hedgehog (SHH), is highly …
maintenance, and tumorigenesis. The activating ligand, Sonic hedgehog (SHH), is highly …
Hedgehog signaling and the primary cilium: implications for spatial and temporal constraints on signaling
The mechanisms of vertebrate Hedgehog signaling are linked to the biology of the primary
cilium, an antenna-like organelle that projects from the surface of most vertebrate cell types …
cilium, an antenna-like organelle that projects from the surface of most vertebrate cell types …
The hedgehog pathway and ocular developmental anomalies
Mutations in effectors of the hedgehog signaling pathway are responsible for a wide variety
of ocular developmental anomalies. These range from massive malformations of the brain …
of ocular developmental anomalies. These range from massive malformations of the brain …
Development of astrocytes in the vertebrate eye
Astrocytes represent the earliest glial population in the embryonic optic nerve, contributing
critically to retinal angiogenesis and formation of brain‐retinal‐barrier. Despite of many …
critically to retinal angiogenesis and formation of brain‐retinal‐barrier. Despite of many …
Genes and pathways in optic fissure closure
A Patel, JC Sowden - Seminars in Cell & Developmental Biology, 2019 - Elsevier
Embryonic development of the vertebrate eye begins with the formation of an optic vesicle
which folds inwards to form a double-layered optic cup with a fissure on the ventral surface …
which folds inwards to form a double-layered optic cup with a fissure on the ventral surface …
Developmental enhancers revealed by extensive DNA methylome maps of zebrafish early embryos
DNA methylation undergoes dynamic changes during development and cell differentiation.
Recent genome-wide studies discovered that tissue-specific differentially methylated …
Recent genome-wide studies discovered that tissue-specific differentially methylated …