The IL-17 family of cytokines in psoriasis: IL-17A and beyond
NC Brembilla, L Senra, WH Boehncke - Frontiers in immunology, 2018 - frontiersin.org
Psoriasis is a frequent chronic inflammatory skin disease, nowadays considered a major
global health problem. Several new drugs, targeting the IL-23/IL-17A pathway, have been …
global health problem. Several new drugs, targeting the IL-23/IL-17A pathway, have been …
[HTML][HTML] How do immune cells overcome the blood–brain barrier in multiple sclerosis?
The presence of the blood–brain barrier (BBB) restricts the movement of soluble mediators
and leukocytes from the periphery to the central nervous system (CNS). Leukocyte entry into …
and leukocytes from the periphery to the central nervous system (CNS). Leukocyte entry into …
DICAM promotes TH17 lymphocyte trafficking across the blood-brain barrier during autoimmune neuroinflammation
M Charabati, C Grasmuck, S Ghannam… - Science Translational …, 2022 - science.org
The migration of circulating leukocytes into the central nervous system (CNS) is a key driver
of multiple sclerosis (MS) pathogenesis. The monoclonal antibody natalizumab proved that …
of multiple sclerosis (MS) pathogenesis. The monoclonal antibody natalizumab proved that …
Th17 cells pathways in multiple sclerosis and neuromyelitis optica spectrum disorders: pathophysiological and therapeutic implications
GRD Passos, DK Sato, J Becker… - Mediators of …, 2016 - Wiley Online Library
Several animal and human studies have implicated CD4+ T helper 17 (Th17) cells and their
downstream pathways in the pathogenesis of central nervous system (CNS) autoimmunity in …
downstream pathways in the pathogenesis of central nervous system (CNS) autoimmunity in …
Shift work at young age is associated with increased risk for multiple sclerosis
Objective: Environmental factors play a prominent role in multiple sclerosis (MS) etiology.
The aim of this study was to investigate the potential association between shift work and MS …
The aim of this study was to investigate the potential association between shift work and MS …
Melanoma cell adhesion molecule identifies encephalitogenic T lymphocytes and promotes their recruitment to the central nervous system
In multiple sclerosis, encephalitogenic CD4+ lymphocytes require adhesion molecules to
accumulate into central nervous system inflammatory lesions. Using proteomic techniques …
accumulate into central nervous system inflammatory lesions. Using proteomic techniques …
The role of Th17 cells in patients with relapsing-remitting multiple sclerosis: interleukin-17A and interleukin-17F serum levels
Background and aims Multiple sclerosis (MS) is an inflammatory condition of the central
nervous system, with genetic and environmental factors having a role in its etiology. The …
nervous system, with genetic and environmental factors having a role in its etiology. The …
Signs of the presence of Th17 cells in chronic periodontal disease
M Adibrad, P Deyhimi… - Journal of …, 2012 - Wiley Online Library
Adibrad M, Deyhimi P, Ganjalikhani Hakemi M, Behfarnia P, Shahabuei M, Rafiee L. Signs
of the presence of Th17 cells in chronic periodontal disease. J Periodont Res 2012; 47: 525 …
of the presence of Th17 cells in chronic periodontal disease. J Periodont Res 2012; 47: 525 …
Bimekizumab: the first dual inhibitor of interleukin (IL)-17A and IL-17F for the treatment of psoriatic disease and ankylosing spondylitis
J Reis, R Vender, T Torres - BioDrugs, 2019 - Springer
Psoriasis is a chronic inflammatory skin disease with significant psychological and physical
impact. Over the last few decades, several highly effective target therapies have been …
impact. Over the last few decades, several highly effective target therapies have been …
Increased IL-17A but decreased IL-27 serum levels in patients with multiple sclerosis
Background: Effector CD4+ T cell subsets play an important role in Multiple Sclerosis (MS).
Interleukin-27 (IL-27) suppresses Th (Th1, Th2 and Th17) cells and dampens autoimmunity …
Interleukin-27 (IL-27) suppresses Th (Th1, Th2 and Th17) cells and dampens autoimmunity …