Background HIV and herpes simplex virus type 2 (HSV-2) infections cause a substantial
global disease burden and are epidemiologically correlated. Two previous systematic …

Herpes simplex viruses (HSV), the causative agents of recurrent orofacial and anogenital
infections, can cause significant morbidity and mortality in both immunocompetent and …

Objective To generate global and regional estimates for the prevalence and incidence of
herpes simplex virus (HSV) type 1 and type 2 infection for 2016. Methods To obtain data, we …

Antiretroviral-based strategies for HIV prevention have shown inconsistent results in women.
We investigated whether vaginal microbiota modulated tenofovir gel microbicide efficacy in …

These guidelines for the treatment of persons who have or are at risk for sexually transmitted
infections (STIs) were updated by CDC after consultation with professionals knowledgeable …

SUMMARY Herpes simplex virus 2 (HSV-2) is a DNA virus that is efficiently transmitted
through intimate genital tract contact and causes persistent infection that cannot be …

Vaginal rings (VRs) are flexible, torus-shaped, polymeric devices designed to sustain
delivery of pharmaceutical drugs to the vagina for clinical benefit. Following first report in a …

Herpes genitalis is caused by the herpes simplex virus type 1 or type 2 and can manifest as
primary or recurrent infection. It is one of the most common sexually transmitted infections …

Genital herpes (GH) is caused by 2 related yet distinct viruses: herpes simplex viruses (HSV)
type-1 (HSV-1) and type-2 (HSV-2). 1 In 2016, there were an estimated 491.5 million people …

Topical pre-exposure prophylaxis (PrEP) with antiretroviral drugs holds promise in
preventing vaginal transmission of HIV. However, significant biomedical and social issues …