The role of ubiquitination and deubiquitination in cancer metabolism
T Sun, Z Liu, Q Yang - Molecular cancer, 2020 - Springer
Metabolic reprogramming, including enhanced biosynthesis of macromolecules, altered
energy metabolism, and maintenance of redox homeostasis, is considered a hallmark of …
energy metabolism, and maintenance of redox homeostasis, is considered a hallmark of …
Deubiquitinases in cancer
Ubiquitination is an essential regulator of most, if not all, signalling pathways, and defects in
cellular signalling are central to cancer initiation, progression and, eventually, metastasis …
cellular signalling are central to cancer initiation, progression and, eventually, metastasis …
Cancer cell-derived exosomal circUSP7 induces CD8+ T cell dysfunction and anti-PD1 resistance by regulating the miR-934/SHP2 axis in NSCLC
SW Chen, SQ Zhu, X Pei, BQ Qiu, D **ong, X Long… - Molecular cancer, 2021 - Springer
Background CD8+ T cells play a critical role in the innate antitumour immune response.
Recently, CD8+ T cell dysfunction has been verified in various malignant cancers, including …
Recently, CD8+ T cell dysfunction has been verified in various malignant cancers, including …
[HTML][HTML] Luteolin suppresses androgen receptor-positive triple-negative breast cancer cell proliferation and metastasis by epigenetic regulation of MMP9 expression …
Background Triple-negative breast cancer (TNBC) represents up to 20% of all breast
cancers. This cancer lacks the expression of the estrogen receptor, progesterone receptor …
cancers. This cancer lacks the expression of the estrogen receptor, progesterone receptor …
[HTML][HTML] DUBs, hypoxia, and cancer
D Mennerich, K Kubaichuk, T Kietzmann - Trends in cancer, 2019 - cell.com
Alterations in protein ubiquitylation and hypoxia are commonly associated with cancer.
Ubiquitylation is carried out by three sequentially acting ubiquitylating enzymes and can be …
Ubiquitylation is carried out by three sequentially acting ubiquitylating enzymes and can be …
METTL4-mediated nuclear N6-deoxyadenosine methylation promotes metastasis through activating multiple metastasis-inducing targets
Abstract Background DNA N6-methyldeoxyadenosine (6mA) is rarely present in mammalian
cells and its nuclear role remains elusive. Results Here we show that hypoxia induces …
cells and its nuclear role remains elusive. Results Here we show that hypoxia induces …
Discovery and characterization of highly potent and selective allosteric USP7 inhibitors
G Gavory, CR O'Dowd, MD Helm, J Flasz… - Nature chemical …, 2018 - nature.com
Given the importance of ubiquitin-specific protease 7 (USP7) in oncogenic pathways,
identification of USP7 inhibitors has attracted considerable interest. Despite substantial …
identification of USP7 inhibitors has attracted considerable interest. Despite substantial …
[HTML][HTML] Reprogramming of the tumor in the hypoxic niche: the emerging concept and associated therapeutic strategies
Hypoxia exerts a profound impact on diverse aspects of cancer biology. Increasing evidence
has revealed novel functions of hypoxia in cancer cell epigenomics, epitranscriptomics …
has revealed novel functions of hypoxia in cancer cell epigenomics, epitranscriptomics …
Targeting hypoxia-inducible factor-1-mediated metastasis for cancer therapy
Z Ma, LZ Wang, JT Cheng, WST Lam, X Ma… - Antioxidants & redox …, 2021 - liebertpub.com
Significance: Hypoxia is emerging as a crucial regulator of the tumor microenvironment; it
governs the metastatic potential of multiple primary cancers. It is also potentially involved in …
governs the metastatic potential of multiple primary cancers. It is also potentially involved in …
Emerging insights into HAUSP (USP7) in physiology, cancer and other diseases
Herpesvirus-associated ubiquitin-specific protease (HAUSP) is a USP family deubiquitinase.
HAUSP is a protein of immense biological importance as it is involved in several cellular …
HAUSP is a protein of immense biological importance as it is involved in several cellular …