Cardiovascular diseases (CVDs), such as ischaemic heart disease, cardiomyopathy,
atherosclerosis, hypertension, stroke and heart failure, are among the leading causes of …

Visualizing the structure and dynamics of biomolecules is critical to understand biological
function, and requires methods to fluorescently label targets of interest in their cellular …

Plant salt-stress response involves complex physiological processes. Previous studies have
shown that some factors promote salt tolerance only under high transpiring condition, thus …

In eukaryotic cells, oxidative protein folding occurs in the lumen of the endoplasmic
reticulum (ER), catalyzed by ER sulfhydryl oxidase 1 (Ero1) and protein disulfide isomerase …

The protein disulphide isomerase (PDI) gene family is a large, diverse group of enzymes
recognised for their roles in disulphide bond formation within the endoplasmic reticulum …

Effector mechanisms of the unfolded protein response (UPR) in the endoplasmic reticulum
(ER) are well-characterised, but how ER proteostasis is sensed is less well understood …

The unfolded protein response (UPR) is a mechanism aiming at restoring endoplasmic
reticulum (ER) homeostasis and is likely involved in other adaptive pathways. The UPR is …

Heat stress (HS), an important factor that affects the physiological state of fish, is known to
induce apoptosis. To investigate relationships among HS, endoplasmic-reticulum stress …

The endoplasmic reticulum (ER) hosts linear polypeptides and fosters natural folding of
proteins through ER-residing chaperones and enzymes. Failure of the ER to align and …

Intestinal goblet cells are secretory cells specialized in the production of mucins, and as
such are challenged by the need for efficient protein folding. Goblet cells express Inositol …