The roots and rhizomes of various species of the perennial herb licorice (Glycyrrhiza) are
used in traditional medicine for the treatment of several diseases. In experimental and …

Metallodrugs have a central role in the treatment and diagnosis of diseases. To overcome
potential toxicity and equip metal-based anticancer agents with biological activity, the choice …

Parasitic infections are among the leading global public health problems with very high
economic and mortality burdens. Unfortunately, the available treatment drugs are beset with …

Glycyrrhizin or, more correctly, Glycyrrhizinic acid is a triterpenoid saponin obtained from the
root and rhizome extracts of Licorice (Glycyrrhiza glabra), being commonly used as a …

Abstract Human carboxylesterase 2 (hCE2), one of the major carboxylesterases in the
human intestine and various tumour tissues, plays important roles in the oral bioavailability …

Malaria is one of the most prevailing fatal diseases causing between 1.2 and 2.7 million
deaths all over the world each year. Further, development of resistance against the frontline …

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Pentacyclic triterpenoids, consisting of six isoprene units, are a kind of natural active
substance. At present, numerous pentacyclic triterpenes have been identified and classified …

Here we report the synthesis of novel chalcone–thiazole compounds and their antifilarial
activity. The antifilarial properties of these hybrids were assessed against microfilariae as …

Lymphatic filariasis is a debilitating vector borne parasitic disease that infects human
lymphatic system by nematode Brugia malayi. Currently available anti-filarial drugs are …