Hexokinases are a family of ubiquitous exose-phosphorylating enzymes that prime glucose
for intracellular utilization. Hexokinase 2 (HK2) is the most active isozyme of the family …

Hepatitis B, C and D viruses (HBV, HCV, HDV, respectively) specifically infect human
hepatocytes and often establish chronic viral infections of the liver, thus esca** antiviral …

With technological advancements, radiotherapy (RT) has become an effective non-surgical
treatment for hepatocellular carcinoma (HCC), comprehensively improving the local control …

Non-alcoholic fatty liver disease (NAFLD) begins with lipid accumulation within hepatocytes,
but the relative contributions of different macronutrients is still unclear. We investigated the …

Glycolytic metabolism generates energy and intermediates for biomass production. Tumor-
associated glycolysis is upregulated compared to normal tissues in response to tumor cell …

HCC has remained one of the challenging cancers to treat, owing to the paucity of drugs
targeting the critical survival pathways. Considering the cancer cells are deficient in DNase …

The reprogramming of energy metabolism is one of the hallmarks of cancer and is crucial for
tumor progression. Altered aerobic glycolysis is a well-known characteristic of cancer cell …

Lactate accumulation and acidification in tumours are a cancer hallmark associated with the
Warburg effect. Lactic acidosis correlates with cancer malignancy, and the benefit it offers to …

Newbouldia laevis, also known as the African Border Tree or Fever Tree, is a deciduous tree
native to West Africa. The plant is valued for its medicinal properties and is used in …

The hypoxia response pathway enables adaptation to oxygen deprivation. It is mediated by
hypoxia-inducible factors (HIF), which promote metabolic reprogramming, erythropoiesis …