Understanding how human genetics influence infectious disease susceptibility offers the
opportunity for new insights into pathogenesis, potential drug targets, risk stratification …

Studies in diverse biological systems have indicated that host–parasite co-evolution is
responsible for the extraordinary genetic diversity seen in some genomic regions, such as …

The current rate of species extinction is rapidly approaching unprecedented highs, and life
on Earth presently faces a sixth mass extinction event driven by anthropogenic activity …

Pathogens and the diseases they cause have been among the most important selective
forces experienced by humans during their evolutionary history. Although adaptive alleles …

The past several years have witnessed an explosion of successful ancient human genome-
sequencing projects, with genomic-scale ancient DNA data sets now available for more than …

Several decades of research have convincingly shown that classical human leukocyte
antigen (HLA) loci bear signatures of natural selection. Despite this conclusion, many …

In spite of the long‐term interest in the process of balancing selection, its frequency in
genomes and evolutionary significance remain unclear due to challenges related to its …

Modern humans inhabit a variety of environments and are exposed to a plethora of selective
pressures, leading to multiple genetic adaptations to local environmental conditions. These …

Population genetics is transitioning into a data-driven discipline thanks to the availability of
large-scale genomic data and the need to study increasingly complex evolutionary …

We report detailed peptide‐binding affinities between 438 HLA Class I and Class II proteins
and complete proteomes of seven pandemic human viruses, including coronaviruses …