Lipid metabolism and Alzheimer's disease: clinical evidence, mechanistic link and therapeutic promise

F Yin - The FEBS journal, 2023 - Wiley Online Library
Alzheimer's disease (AD) is an age‐associated neurodegenerative disorder with
multifactorial etiology, intersecting genetic and environmental risk factors, and a lack of …

Inflammation: the link between comorbidities, genetics, and Alzheimer's disease

EA Newcombe, J Camats-Perna, ML Silva… - Journal of …, 2018 - Springer
Alzheimer's disease (AD) is a neurodegenerative disorder, most cases of which lack a clear
causative event. This has made the disease difficult to characterize and, thus, diagnose …

Bioactive lipids, inflammation and chronic diseases

A Leuti, D Fazio, M Fava, A Piccoli, S Oddi… - Advanced Drug Delivery …, 2020 - Elsevier
Endogenous bioactive lipids are part of a complex network that modulates a plethora of
cellular and molecular processes involved in health and disease, of which inflammation …

Anti-inflammatory effects of omega-3 fatty acids in the brain: physiological mechanisms and relevance to pharmacology

S Laye, A Nadjar, C Joffre, RP Bazinet - Pharmacological reviews, 2018 - Elsevier
Classically, polyunsaturated fatty acids (PUFA) were largely thought to be relatively inert
structural components of brain, largely important for the formation of cellular membranes …

Physical exercise induces hippocampal neurogenesis and prevents cognitive decline

CL Ma, XT Ma, JJ Wang, H Liu, YF Chen… - Behavioural brain …, 2017 - Elsevier
Accumulating evidence from animal and human research indicate that adult hippocampal
neurogenesis plays a key role in cognition. Meanwhile, cognitive decline is well known to …

Dementia and the risk of periodontitis: a population-based cohort study

KS Ma, H Hasturk, I Carreras… - Journal of dental …, 2022 - journals.sagepub.com
Dementia and Alzheimer's disease (AD) are proposed to be comorbid with periodontitis
(PD). It is unclear whether PD is associated with dementia and AD independent of …

Fatty acid metabolism in the progression and resolution of CNS disorders

JFJ Bogie, M Haidar, G Kooij, JJA Hendriks - Advanced drug delivery …, 2020 - Elsevier
Recent advances in lipidomics and metabolomics have unveiled the complexity of fatty acid
metabolism and the fatty acid lipidome in health and disease. A growing body of evidence …

Lipoxins and aspirin-triggered lipoxins in resolution of inflammation

M Romano, E Cianci, F Simiele, A Recchiuti - European journal of …, 2015 - Elsevier
The resolution of the inflammatory response is highly regulated by the timely biosynthesis of
a number of endogenous lipid mediators. Among these, lipoxins (LX) and their 15-epimers …

Neuroinflammation and neurohormesis in the pathogenesis of Alzheimer's disease and Alzheimer-linked pathologies: modulation by nutritional mushrooms

A Trovato Salinaro, M Pennisi, R Di Paola, M Scuto… - Immunity & …, 2018 - Springer
Human life develops and expands not only in time and space, but also in the retrograde
permanent recollection and interweaving of memories. Therefore, individual human identity …

Expert consensus report on lipid mediators: role in resolution of inflammation and muscle preservation

CN Serhan, M Bäck, V Chiurchiù, M Hersberger… - 2024 - Wiley Online Library
This meeting report presents a consensus on the biological aspects of lipid emulsions in
parenteral nutrition, emphasizing the unanimous support for the integration of lipid …