Abstract Polycystin-2 (TRPP2, PKD2, PC2) is the product of the PKD2 gene, whose
mutations cause Autosomal Dominant Polycystic Kidney Disease (ADPKD). PC2 belongs to …

Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in the
PKD1 or PKD2 gene which encodes membrane receptor PKD1 and cation channel PKD2 …

Calcium release from the endoplasmic reticulum (ER) is predominantly driven by two key ion
channel receptors, inositol 1, 4, 5‐triphosphate receptor (InsP3R) in non‐excitable cells and …

Cardiovascular complications in patients with autosomal dominant polycystic kidney disease
(ADPKD) are frequently investigated extrarenal manifestations with contradictory outcomes …

Cardiovascular disease is the major cause of mortality in autosomal dominant polycystic
kidney disease and contributes to significant burden of disease. The manifestations are …

The development of skeletal muscle (myogenesis) is a well-orchestrated process where
myoblasts withdraw from the cell cycle and differentiate into myotubes. Signaling by fluxes in …

Background and Objective: To explore the molecular mechanism by which Shengmaiyin
(Codonopsis pilosula)(SMY) improves isoproterenol (ISO)-induced heart failure (HF) in rats …

Calcium signaling is a critical process required for cellular mechanisms such as
cardiomyocyte contraction. The inability of the cell to properly activate or regulate calcium …

Diabetes is commonly associated with an elevated level of reactive carbonyl species due to
alteration of glucose and fatty acid metabolism. These metabolic changes cause an …

Background: Hypertension is seen in 70% of autosomal dominant polycystic kidney disease
(ADPKD) patients by the age of 30 prior to decline in kidney function. However, cardiac …