The most successful obesity therapeutics, glucagon-like peptide-1 receptor (GLP1R)
agonists, cause aversive responses such as nausea and vomiting,, effects that may …

The hypothalamic arcuate nucleus dopaminergic (A12) neurons are well-known for their
central role in regulating prolactin secretion through a sophisticated negative feedback loop …

Thyrotropin-releasing hormone (TRH; pGlu-His-Pro-NH2) is an intercellular signal produced
mainly by neurons. Among the multiple pharmacological effects of TRH, that on food intake …

Leptin is an adipose tissue hormone that maintains homeostatic control of adipose tissue
mass by regulating the activity of specific neural populations controlling appetite and …

Introduction: Owing to their privileged anatomical location, neurons of the arcuate nucleus of
the hypothalamus (ARC) play critical roles in sensing and responding to metabolic signals …

Highlights•Nausea protects against intoxication, but chronic nausea can be
problematic.•Nausea routes include the area postrema, vagus nerve, and vestibular …

Analogs of the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent
insulinotropic peptide (GIP) have become mainstays of obesity and diabetes management …

Glucagon-like peptide-1 receptor agonists (GLP1RAs) effectively reduce body weight and
improve metabolic outcomes, yet established peptide-based therapies require injections …

The use of incretin analogues has emerged in recent years as an effective approach to
achieve both enhanced insulin secretion and weight loss in type 2 diabetes (T2D) patients …

In the gut and brain, prohormone convertase (PC) 1/3 expression processes proglucagon
into five distinct peptides, including glucagon-like peptide-1 (GLP-1). In the pancreas, PC2 …