Tissue injury initiates a complex repair process, which in some organisms can lead to the
complete regeneration of a tissue. In mammals, however, the repair of most organs is …

The fibroblast growth factor (FGF) family is composed of 18 secreted signaling proteins
consisting of canonical FGFs and endocrine FGFs that activate four receptor tyrosine …

Zebrafish have the remarkable ability to fully regenerate a lost appendage, faithfully
restoring its size, shape and tissue patterning. Studies over the past decades have identified …

Dedifferentiation of mature cells is an intriguing cellular process associated with
regeneration of several organs. During zebrafish fin regeneration, osteoblasts …

Highly regenerative animals can regrow lost appendages and the rate of regrowth is
proportional to the amount of appendage loss. This century-old phenomenon prompted us to …

Studies have shown that fibroblast growth factor (Fgf) signalling is necessary for appendage
regeneration, but its exact function and the ligands involved during regeneration have not …

Adult zebrafish are able to heal large-sized cutaneous wounds in hours with little to no
scarring. This rapid re-epithelialization is crucial for preventing infection and jumpstarting the …

Successful regeneration requires the coordinated execution of multiple cellular responses to
injury. In amputated zebrafish fins, mature osteoblasts dedifferentiate, migrate towards the …

Extracellular matrix (ECM) proteins are major components of most tissues and organs. In
addition to their crucial role in tissue cohesion and biomechanics, they chiefly regulate …

Many organs regenerate well in adult zebrafish, but most research has been directed toward
fin and heart regeneration. Cells have been found to remain generally lineage-restricted …