The trace element zinc is required for proper functioning of a large number of proteins,
including various enzymes. However, most zinc-containing proteins are transcription factors …

▪ Abstract Protein complexes consisting of s tructural m aintenance of c hromosomes (SMC)
and kleisin subunits are crucial for the faithful segregation of chromosomes during cell …

Haploinsufficiency is defined as a dominant phenotype in diploid organisms that are
heterozygous for a loss-of-function allele. Despite its relevance to human disease, neither …

Nearly 20% of yeast genes are required for viability, hindering genetic analysis with
knockouts. We created promoter-shutoff strains for over two-thirds of all essential yeast …

Through a genetic screen using myosin-like protein strains mlp1 Δ mlp2 Δ and biochemical
purification, we identified a complex of eight proteins, each required for growth and DNA …

Functional analysis of the proteome is an essential part of genomic research. To facilitate
different proteomic approaches, a MORF (moveable ORF) library of 5854 yeast expression …

Controlled vocabularies are increasingly used by databases to describe genes and gene
products because they facilitate identification of similar genes within an organism or among …

FlyMine is a data warehouse that addresses one of the important challenges of modern
biology: how to integrate and make use of the diversity and volume of current biological …

Structural maintenance of chromosomes (SMC) proteins are chromosomal ATPases, highly
conserved from bacteria to humans, that play fundamental roles in many aspects of higher …

The yeast two-hybrid system pioneered the field of in vivo protein-protein interaction
methods and undisputedly gave rise to a palette of ingenious techniques that are constantly …