Abstract The ECFS-CTN Standardisation Committee has undertaken this review of lung
clearance index as part of the group's work on evaluation of clinical endpoints with regard to …

Background: Obstructive airway disease is nonuniformly distributed throughout the bronchial
tree, although the extent to which this occurs can vary among conditions. The multiple …

Inert gas washout tests, performed using the single-or multiple-breath washout technique,
were first described over 60 years ago. As measures of ventilation distribution …

Nitrogen multiple-breath washout is an established technique to assess functional residual
capacity and ventilation inhomogeneity in the lung. Accurate measurement of gas …

Rationale: The lung clearance index is a measure of ventilation distribution derived from the
multiple-breath washout technique. It has been suggested as a surrogate for chest …

Rationale: Lung clearance index (LCI), measured by multiple breath washout (MBW), is a
noninvasive measure of ventilation inhomogeneity that holds promise as an objective …

Structural and functional defects within the lungs of children with cystic fibrosis (CF) are
detectable soon after birth and progress throughout preschool years often without overt …

Suboptimal asthma control is common despite modern asthma therapy. The degree of
peripheral airway involvement remains unclear and poor medication delivery to these …

Background Although lung clearance index (LCI) is a sensitive indicator of mild cystic
fibrosis (CF) lung disease, it is rarely measured due to lengthy protocols and the commercial …

Background The lung clearance index (LCI), measured by multiple breath washout (MBW),
reflects global ventilation inhomogeneity and is a sensitive marker of early cystic fibrosis …