Lipofuscin accumulates with age as intracellular fluorescent granules originating from
incomplete lysosomal digestion of phagocytosed and autophagocytosed material. The …

Hyperspectral imaging is a frontier in the field of medical imaging technology. It enables the
simultaneous collection of spectroscopic and spatial data. Structural and physiological …

Bestrophinopathies, one of the most common forms of inherited macular degenerations, are
caused by mutations in the BEST1 gene expressed in the retinal pigment epithelium (RPE) …

Alzheimer's disease (AD) is a major risk for the aging population. The pathological hallmarks
of AD—an abnormal deposition of amyloid β-protein (Aβ) and phosphorylated tau (pTau) …

Purpose: Hyperspectral imaging is gaining attention in the biomedical field because it
generates additional spectral information to study physiological and clinical processes …

Purpose: To elucidate the molecular pathogenesis of age-related macular degeneration
(AMD) and interpretation of fundus autofluorescence imaging, the authors identified spectral …

Hyperspectral imaging (HSI) is a form of spectral imaging pioneered for remote sensing
satellite imaging in agriculture and water control (Fig. 1). 1 HSI collects data from across the …

Purpose: The purpose of this study was to observe changes of the retinal pigment epithelium
(RPE) on the transition from dysmorphia to atrophy in age-related macular degeneration …

Simple Summary The ocular fundus contains molecules that emit fluorescence when excited
with light of an appropriate wavelength. Fundus autofluorescence imaging is based on the in …

Purpose: To investigate the major organelles of the retinal pigment epithelium (RPE) in wild-
type (WT, control) mice and their changes in pigmented Abca4 knockout (Abca4−/−) mice …