Mitochondria are double-membrane organelles that provide the majority of a cell's energy.
Furthermore, mitochondria are involved in various cellular biological activities, including …

Nav1. 5 is the predominant cardiac sodium channel subtype, encoded by the SCN5A gene,
which is involved in the initiation and conduction of action potentials throughout the heart …

Background Atrial fibrillation (AF) is the most common type of arrhythmia. Abnormal atrial
myocyte Ca 2+ handling promotes aberrant membrane excitability and remodeling that are …

Cardiac arrhythmias are common, often the first, and sometimes the life-threatening
manifestations of hereditary cardiomyopathies. Pathogenic variants in several genes known …

Cardiovascular disease is the leading cause of death worldwide. In spite of the mature
managements of myocardial infarction (MI), post-MI reperfusion (I/R) injury results in high …

Nav1. 6 is the primary voltage-gated sodium channel isoform expressed in mature axon
initial segments and nodes, making it critical for initiation and propagation of neuronal …

The voltage-gated sodium channel Nav1. 5 initiates the cardiac action potential. Alterations
of its activation and inactivation properties due to mutations can cause severe, life …

Cardiac voltage‐gated ion channels (VGICs) play critical roles in mediating cardiac
electrophysiological signals, such as action potentials, to maintain normal heart excitability …

Pathological cardiac hypertrophy eventually leads to heart failure without adequate
treatment. REGγ is emerging as 11S proteasome activator of 20S proteasome to promote …

Previous studies have shown an attenuating effect of ginsenoside Re on myocardial injury
induced by hypoxia/reoxygenation (H/R). However, the underlying mechanism remains …