The incorporation of a synthetic, catalytically competent metallocofactor into a protein
scaffold to generate an artificial metalloenzyme (ArM) has been explored since the late …

Conspectus In nature, heme cofactor-containing proteins participate not only in electron
transfer and O2 storage and transport but also in biosynthesis and degradation. The …

The ability of natural metalloproteins to prevent inactivation of their metal cofactors by
biological metabolites, such as glutathione, is an area that has been largely ignored in the …

Water is one of the most abundant molecules on earth. It is inexpensive, especially when
compared to organic solvents, nonflammable, and nontoxic, it has a large heat capacity, and …

An emerging approach in the field of targeted drug delivery is the establishment of abiotic
metal‐triggered prodrug mechanisms that can control the release of bioactive drugs …

The design of artificial enzymes has emerged as a promising tool for the generation of
potent biocatalysts able to promote new‐to‐nature reactions with improved catalytic …

Highlights•Recent advances in the field of artificial metalloenzymes with a particular focus
on enantioselective catalysis are described.•New design strategies for artificial …

Metalloenzymes efficiently catalyze some of the most important and difficult reactions in
nature. For many years, coordination chemists have effectively used small molecule models …

Highlights•Artificial metalloenzymes result from incorporation of a metal cofactor in a
protein.•These biohybrids catalyze abiotic transformations.•Artificial metalloenzymes can be …

Hirshfeld surface analysis has been widely used in recent years as a means to quantify and
visualize various types of intermolecular interactions in molecular crystals. This review …