Contemporary medicinal chemistry faces diverse challenges from several directions,
including the need for both potency and specificity of any therapeutic agent; the increasingly …

Spirocyclic pyrrolidines are structural motifs frequently found in a wide variety of natural
products, pharmaceuticals and biologically significant compounds. In the past few years …

Pollutants from industry and chemical laboratories have harmful effects on human health
and the environment. Concerns about this problem have led to the development of more …

Drug discovery and development is a complex and lengthy enterprise that suffers from high
rates of candidate attrition at all stages of the process. The physical, biological, and …

Chroman-4-one scaffold is a privileged structure in heterocyclic chemistry and drug
discovery. Also, chroman-4-ones are important intermediates and interesting building blocks …

Abstract 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) interconverts the inactive
glucocorticoid cortisone and its active form cortisol. It is widely expressed and, although …

Spirocyclic compounds are abundant in biologically active products. However, the divergent
synthesis of spirocyclic compounds using low-cost and abundant available starting materials …

Photocatalytic deoxygenative carboimination of unstrained γ, δ‐unsaturated oximes with π‐
acceptors including trifluoromethyl alkenes, 1‐trifluoromethyl‐1, 3‐butadienes, gem …

11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) is the enzyme primarily responsible
for the regulation of intracellular cortisol levels. Inhibition of 11β-HSD1 is an attractive …

We propose a numerical framework that permits an effective atlas-like representation of
chemico-biological space based on a series of Cartesian planes map** the ligands with …