[HTML][HTML] Recent advances in the development of metal complexes as antibacterial agents with metal-specific modes of action

JE Waters, L Stevens-Cullinane, L Siebenmann… - Current Opinion in …, 2023 - Elsevier
The mounting burden of antimicrobial resistance (AMR) is one of the most concerning
threats to public health worldwide. With low economic incentives and a dwindling supply of …

[HTML][HTML] Approaches to the design of catalytic metallodrugs

JJ Soldevila-Barreda, PJ Sadler - Current Opinion in Chemical Biology, 2015 - Elsevier
Highlights•How can metal catalysts be used for biochemical transformations?•Catalysis by
metal complexes can even be achieved in cells.•Catalysis includes C single bond C bond …

Transfer hydrogenation catalysis in cells as a new approach to anticancer drug design

JJ Soldevila-Barreda, I Romero-Canelón… - Nature …, 2015 - nature.com
Organometallic complexes are effective hydrogenation catalysts for organic reactions. For
example, Noyori-type ruthenium complexes catalyse reduction of ketones by transfer of …

Designed metal-ATCUN derivatives: Redox-and non-redox-based applications relevant for chemistry, biology, and medicine

BK Maiti, N Govil, T Kundu, JJG Moura - IScience, 2020 - cell.com
The designed" ATCUN" motif (amino-terminal copper and nickel binding site) is a replica of
naturally occurring ATCUN site found in many proteins/peptides, and an attractive platform …

Catalytic azide reduction in biological environments

PK Sasmal, S Carregal‐Romero, AA Han… - …, 2012 - Wiley Online Library
In the quest for the identification of catalytic transformations to be used in chemical biology
and medicinal chemistry, we identified iron (III) meso‐tetraarylporphines as efficient catalysts …

[HTML][HTML] Reduction of quinones by NADH catalyzed by organoiridium complexes

Z Liu, RJ Deeth, JS Butler, A Habtemariam… - … (International ed. in …, 2013 - ncbi.nlm.nih.gov
Quinones (Q) are a class of fully conjugated cyclic dione compounds that are widely
distributed in nature.[1] They can function as electron carriers in electron-transport chains …

Nickel (II)-Schiff base complex recognizing domain II of bovine and human serum albumin: Spectroscopic and docking studies

A Ray, BK Seth, U Pal, S Basu - Spectrochimica Acta Part A: Molecular and …, 2012 - Elsevier
It has been spectroscopically monitored that a mononuclear nickel (II)-Schiff base complex
{[NiL]· CH3OH= NSC} exhibits greater binding affinity for bovine serum albumin (BSA) than …

Factors influencing the DNA nuclease activity of iron, cobalt, nickel, and copper chelates

JC Joyner, J Reichfield, JA Cowan - Journal of the American …, 2011 - ACS Publications
A library of complexes that included iron, cobalt, nickel, and copper chelates of cyclam,
cyclen, DOTA, DTPA, EDTA, tripeptide GGH, tetrapeptide KGHK, NTA, and TACN was …

Toward the Design of a Catalytic Metallodrug: Selective Cleavage of G‐Quadruplex Telomeric DNA by an Anticancer Copper–Acridine–ATCUN Complex

Z Yu, M Han, JA Cowan - Angewandte Chemie, 2015 - Wiley Online Library
Telomeric DNA represents a novel target for the development of anticancer drugs. By
application of a catalytic metallodrug strategy, a copper–acridine–ATCUN complex …

Anticancer activity and catalytic potential of ruthenium (II)–arene complexes with N, O-donor ligands

MM Haghdoost, J Guard, G Golbaghi… - Inorganic …, 2018 - ACS Publications
The special ability of organometallic complexes to catalyze various transformations might
offer new effective mechanisms for the treatment of cancer. Studies that report both the …