[HTML][HTML] Recent advances in the development of metal complexes as antibacterial agents with metal-specific modes of action
JE Waters, L Stevens-Cullinane, L Siebenmann… - Current Opinion in …, 2023 - Elsevier
The mounting burden of antimicrobial resistance (AMR) is one of the most concerning
threats to public health worldwide. With low economic incentives and a dwindling supply of …
threats to public health worldwide. With low economic incentives and a dwindling supply of …
[HTML][HTML] Approaches to the design of catalytic metallodrugs
JJ Soldevila-Barreda, PJ Sadler - Current Opinion in Chemical Biology, 2015 - Elsevier
Highlights•How can metal catalysts be used for biochemical transformations?•Catalysis by
metal complexes can even be achieved in cells.•Catalysis includes C single bond C bond …
metal complexes can even be achieved in cells.•Catalysis includes C single bond C bond …
Transfer hydrogenation catalysis in cells as a new approach to anticancer drug design
JJ Soldevila-Barreda, I Romero-Canelón… - Nature …, 2015 - nature.com
Organometallic complexes are effective hydrogenation catalysts for organic reactions. For
example, Noyori-type ruthenium complexes catalyse reduction of ketones by transfer of …
example, Noyori-type ruthenium complexes catalyse reduction of ketones by transfer of …
Designed metal-ATCUN derivatives: Redox-and non-redox-based applications relevant for chemistry, biology, and medicine
The designed" ATCUN" motif (amino-terminal copper and nickel binding site) is a replica of
naturally occurring ATCUN site found in many proteins/peptides, and an attractive platform …
naturally occurring ATCUN site found in many proteins/peptides, and an attractive platform …
Catalytic azide reduction in biological environments
In the quest for the identification of catalytic transformations to be used in chemical biology
and medicinal chemistry, we identified iron (III) meso‐tetraarylporphines as efficient catalysts …
and medicinal chemistry, we identified iron (III) meso‐tetraarylporphines as efficient catalysts …
[HTML][HTML] Reduction of quinones by NADH catalyzed by organoiridium complexes
Z Liu, RJ Deeth, JS Butler, A Habtemariam… - … (International ed. in …, 2013 - ncbi.nlm.nih.gov
Quinones (Q) are a class of fully conjugated cyclic dione compounds that are widely
distributed in nature.[1] They can function as electron carriers in electron-transport chains …
distributed in nature.[1] They can function as electron carriers in electron-transport chains …
Nickel (II)-Schiff base complex recognizing domain II of bovine and human serum albumin: Spectroscopic and docking studies
It has been spectroscopically monitored that a mononuclear nickel (II)-Schiff base complex
{[NiL]· CH3OH= NSC} exhibits greater binding affinity for bovine serum albumin (BSA) than …
{[NiL]· CH3OH= NSC} exhibits greater binding affinity for bovine serum albumin (BSA) than …
Factors influencing the DNA nuclease activity of iron, cobalt, nickel, and copper chelates
JC Joyner, J Reichfield, JA Cowan - Journal of the American …, 2011 - ACS Publications
A library of complexes that included iron, cobalt, nickel, and copper chelates of cyclam,
cyclen, DOTA, DTPA, EDTA, tripeptide GGH, tetrapeptide KGHK, NTA, and TACN was …
cyclen, DOTA, DTPA, EDTA, tripeptide GGH, tetrapeptide KGHK, NTA, and TACN was …
Toward the Design of a Catalytic Metallodrug: Selective Cleavage of G‐Quadruplex Telomeric DNA by an Anticancer Copper–Acridine–ATCUN Complex
Z Yu, M Han, JA Cowan - Angewandte Chemie, 2015 - Wiley Online Library
Telomeric DNA represents a novel target for the development of anticancer drugs. By
application of a catalytic metallodrug strategy, a copper–acridine–ATCUN complex …
application of a catalytic metallodrug strategy, a copper–acridine–ATCUN complex …
Anticancer activity and catalytic potential of ruthenium (II)–arene complexes with N, O-donor ligands
MM Haghdoost, J Guard, G Golbaghi… - Inorganic …, 2018 - ACS Publications
The special ability of organometallic complexes to catalyze various transformations might
offer new effective mechanisms for the treatment of cancer. Studies that report both the …
offer new effective mechanisms for the treatment of cancer. Studies that report both the …