Immunobiology and pathogenesis of hepatitis B virus infection
Hepatitis B virus (HBV) is a non-cytopathic, hepatotropic virus with the potential to cause a
persistent infection, ultimately leading to cirrhosis and hepatocellular carcinoma. Over the …
persistent infection, ultimately leading to cirrhosis and hepatocellular carcinoma. Over the …
Therapeutic strategies for hepatitis B virus infection: towards a cure
Chronic hepatitis B virus (HBV) infection is a common cause of liver disease globally, with a
disproportionately high burden in South-East Asia. Vaccines and nucleoside or nucleotide …
disproportionately high burden in South-East Asia. Vaccines and nucleoside or nucleotide …
Global burden of NAFLD and chronic liver disease among adolescents and young adults
JM Paik, K Kabbara, KE Eberly, Y Younossi, L Henry… - Hepatology, 2022 - journals.lww.com
Conclusions HBV cccDNA minichromosomes in distinct epigenetic transcriptional states
showed a similar reduction rate during cell division but significantly differed in their …
showed a similar reduction rate during cell division but significantly differed in their …
A roadmap for serum biomarkers for hepatitis B virus: current status and future outlook
A Kramvis, KM Chang, M Dandri, P Farci… - Nature Reviews …, 2022 - nature.com
Globally, 296 million people are infected with hepatitis B virus (HBV), and approximately one
million people die annually from HBV-related causes, including liver cancer. Although there …
million people die annually from HBV-related causes, including liver cancer. Although there …
Progress towards elimination goals for viral hepatitis
The global burden of viral hepatitis is substantial; in terms of mortality, hepatitis B virus and
hepatitis C virus infections are on a par with HIV, malaria and tuberculosis, among the top …
hepatitis C virus infections are on a par with HIV, malaria and tuberculosis, among the top …
The scientific basis of combination therapy for chronic hepatitis B functional cure
Functional cure of chronic hepatitis B (CHB)—or hepatitis B surface antigen (HBsAg) loss
after 24 weeks off therapy—is now the goal of treatment, but is rarely achieved with current …
after 24 weeks off therapy—is now the goal of treatment, but is rarely achieved with current …
Hepatitis B virus persistence and reactivation
Y Shi, M Zheng - bmj, 2020 - bmj.com
Hepatitis B virus (HBV) infection causes chronic hepatitis and has long term complications.
Individuals ever infected with HBV are at risk of viral reactivation under certain …
Individuals ever infected with HBV are at risk of viral reactivation under certain …
Dual-targeting nanoparticle vaccine elicits a therapeutic antibody response against chronic hepatitis B
W Wang, X Zhou, Y Bian, S Wang, Q Chai… - Nature …, 2020 - nature.com
Chronic hepatitis B is caused by prolonged infection with the hepatitis B virus (HBV), which
can substantially increase the risk of develo** liver disease. Despite the development of …
can substantially increase the risk of develo** liver disease. Despite the development of …
CD8 cis-targeted IL-2 drives potent antiviral activity against hepatitis B virus
CD8+ T cells are key antiviral effectors against hepatitis B virus (HBV), yet their number and
function can be compromised in chronic infections. Preclinical HBV models displaying CD8+ …
function can be compromised in chronic infections. Preclinical HBV models displaying CD8+ …
The evolution and clinical impact of hepatitis B virus genome diversity
The global burden of hepatitis B virus (HBV) is enormous, with 257 million persons
chronically infected, resulting in more than 880,000 deaths per year worldwide. HBV exists …
chronically infected, resulting in more than 880,000 deaths per year worldwide. HBV exists …