It has recently been appreciated that atherosclerosis is predominantly an inflammatory
process. Atherosclerosis begins with a fatty streak, which is made up almost entirely of …

Atherosclerosis, formerly considered a bland lipid storage disease, actually involves an
ongoing inflammatory response. Recent advances in basic science have established a …

Atherosclerosis (AS) is the formation of plaques in blood vessels, which leads to serious
cardiovascular diseases. Current research has disclosed that the formation of AS plaques is …

A key event in atherosclerosis is a maladaptive inflammatory response to subendothelial
lipoproteins. A crucial aspect of this response is a failure to resolve inflammation, which …

The majority of patients with acute coronary syndromes (ACS) present with unstable angina,
acute myocardial infarction, and sudden coronary death. The most common cause of …

The G protein-coupled receptor TGR5 has been identified as an important component of the
bile acid signaling network, and its activation has been linked to enhanced energy …

Membrane lipids are essential for biological functions ranging from membrane trafficking to
signal transduction. The composition of lipid membranes influences their organization and …

Background—Excessive lipid accumulation in macrophages plays an important role in the
development of atherosclerosis. Recently, we discovered an adipocyte-specific plasma …

Background N-3 polyunsaturated fatty acids (PUFAs) from oily fish protect against death
from cardiovascular disease. We aimed to assess the hypothesis that incorporation of n-3 …

Prolonged activation of the endoplasmic reticulum (ER) stress pathway known as the
unfolded protein response (UPR) can lead to cell pathology and subsequent tissue …