Stimulus-cleavable chemistry in the field of controlled drug delivery

Y Xue, H Bai, B Peng, B Fang, J Baell, L Li… - Chemical Society …, 2021 - pubs.rsc.org
Stimulus-cleavable nanoscale drug delivery systems are receiving significant attention
owing to their capability of achieving exquisite control over drug release via the exposure to …

Polymeric micelles: Basic research to clinical practice

AS Deshmukh, PN Chauhan, MN Noolvi… - International journal of …, 2017 - Elsevier
Rapidly develo** polymeric micelles as potential targeting carriers has intensified the
need for better understanding of the underlying principles related to the selection of suitable …

Hydrazone linkages in pH responsive drug delivery systems

SJ Sonawane, RS Kalhapure, T Govender - European Journal of …, 2017 - Elsevier
Stimuli-responsive polymeric drug delivery systems using various triggers to release the
drug at the sites have become a major focus area. Among various stimuli-responsive …

Micelles based on acid degradable poly (acetal urethane): preparation, pH-sensitivity, and triggered intracellular drug release

F Huang, R Cheng, F Meng, C Deng… - Biomacromolecules, 2015 - ACS Publications
Polyurethanes are a unique class of biomaterials that are widely used in medical devices. In
spite of their easy synthesis and excellent biocompatibility, polyurethanes are less explored …

Targeted Delivery of Anticancer Therapeutics with Polymers by Harnessing Tumor Microenvironment Acidity

J Shi, B Ma, Y Zhang, H Yong, Z Li, X Huang… - Chemistry of …, 2023 - ACS Publications
Cancer therapy is a global biomedical challenge, and a number of promising anticancer
therapeutics, such as small-molecule drugs, proteins, nucleic acids, photothermal agents …

Acetal-linked polymeric prodrug micelles for enhanced curcumin delivery

M Li, M Gao, Y Fu, C Chen, X Meng, A Fan… - Colloids and Surfaces B …, 2016 - Elsevier
On-demand curcumin delivery via stimuli-responsive micellar nanocarriers holds promise for
addressing its solubility and stability problem. Polymer-curcumin prodrug conjugate micelle …

Multistage pH-responsive mesoporous silica nanohybrids with charge reversal and intracellular release for efficient anticancer drug delivery

X Yuan, S Peng, W Lin, J Wang, L Zhang - Journal of colloid and interface …, 2019 - Elsevier
This study introduced multistage pH-responsive nanohybrids (MSN-hyd-MOP) based on
mesoporous silica nanoparticles (MSNs) modified with polymers with charge-reversal …

Encapsulation of isoniazid-conjugated phthalocyanine-in-cyclodextrin-in-liposomes using heating method

CI Nkanga, RWM Krause - Scientific reports, 2019 - nature.com
Liposomes are reputed colloidal vehicles that hold the promise for targeted delivery of anti-
tubercular drugs (ATBDs) to alveolar macrophages that host Mycobacterium tuberculosis …

Small molecular nanomedicines made from a camptothecin dimer containing a disulfide bond

Q Pei, X Hu, Z Li, Z **e, X **g - RSC advances, 2015 - pubs.rsc.org
A small molecular camptothecin (CPT) dimer could self-assemble into stable nanoparticles
in aqueous solution, which was characterized by TEM and DLS. These nanomedicines …

Hyaluronic acid-tacrolimus bioconjugate: synthesis, characterization, and pharmacokinetic investigation of an acid-responsive macromolecular prodrug

D Dheer, R Gupta, D Singh, A Magotra… - ACS Applied Bio …, 2019 - ACS Publications
Polymer-drug conjugates have been the cornerstone of several drug delivery systems owing
to their numerous benefits such as improved drug solubilization, controlled release …