Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis
WH Robinson, CM Lepus, Q Wang, H Raghu… - Nature Reviews …, 2016 - nature.com
Osteoarthritis (OA) has long been viewed as a degenerative disease of cartilage, but
accumulating evidence indicates that inflammation has a critical role in its pathogenesis …
accumulating evidence indicates that inflammation has a critical role in its pathogenesis …
Role of proinflammatory cytokines in the pathophysiology of osteoarthritis
M Kapoor, J Martel-Pelletier, D Lajeunesse… - Nature Reviews …, 2011 - nature.com
Osteoarthritis (OA) is associated with cartilage destruction, subchondral bone remodeling
and inflammation of the synovial membrane, although the etiology and pathogenesis …
and inflammation of the synovial membrane, although the etiology and pathogenesis …
Association of pharmacological treatments with long-term pain control in patients with knee osteoarthritis: a systematic review and meta-analysis
Importance Even though osteoarthritis is a chronic and progressive disease,
pharmacological agents are mainly studied over short-term periods, resulting in unclear …
pharmacological agents are mainly studied over short-term periods, resulting in unclear …
Role of inflammation in the pathogenesis of osteoarthritis: latest findings and interpretations
J Sokolove, CM Lepus - Therapeutic advances in …, 2013 - journals.sagepub.com
Osteoarthritis (OA) has traditionally been classified as a noninflammatory arthritis; however,
the dichotomy between inflammatory and degenerative arthritis is becoming less clear with …
the dichotomy between inflammatory and degenerative arthritis is becoming less clear with …
[HTML][HTML] EULAR recommendations for the use of imaging in the clinical management of peripheral joint osteoarthritis
The increased information provided by modern imaging has led to its more extensive use.
Our aim was to develop evidence-based recommendations for the use of imaging in the …
Our aim was to develop evidence-based recommendations for the use of imaging in the …
Clinical pharmacology of non-steroidal anti-inflammatory drugs: a review
Non-steroidal anti-inflammatory drugs (NSAIDs) are a group of often chemically unrelated
compounds with some common therapeutic actions and side effects. They have potent anti …
compounds with some common therapeutic actions and side effects. They have potent anti …
[HTML][HTML] Comparative pain reduction of oral non-steroidal anti-inflammatory drugs and opioids for knee osteoarthritis: systematic analytic review
Objective Summarize the comparative effectiveness of oral non-steroidal anti-inflammatory
drugs (NSAIDs) and opioids in reducing knee osteoarthritis (OA) pain. Methods Two …
drugs (NSAIDs) and opioids in reducing knee osteoarthritis (OA) pain. Methods Two …
Disease-modifying drugs in osteoarthritis: current understanding and future therapeutics
Introduction: Osteoarthritis (OA) is a leading cause of pain and disability among adults with a
current prevalence of around 15% and a predicted prevalence of 35% in 2030 for …
current prevalence of around 15% and a predicted prevalence of 35% in 2030 for …
Intraarticular sprifermin (recombinant human fibroblast growth factor 18) in knee osteoarthritis: a randomized, double‐blind, placebo‐controlled trial
LS Lohmander, S Hellot, D Dreher… - Arthritis & …, 2014 - Wiley Online Library
Objective To evaluate the efficacy and safety of intraarticular sprifermin (recombinant human
fibroblast growth factor 18) in the treatment of symptomatic knee osteoarthritis (OA). Methods …
fibroblast growth factor 18) in the treatment of symptomatic knee osteoarthritis (OA). Methods …
Effect of vitamin D supplementation on progression of knee pain and cartilage volume loss in patients with symptomatic osteoarthritis: a randomized controlled trial
Importance Knee osteoarthritis (OA), a disorder of cartilage and periarticular bone, is a
public health problem without effective medical treatments. Some studies have suggested …
public health problem without effective medical treatments. Some studies have suggested …