Macrophages are innate immune cells that form a 3D network in all our tissues, where they
phagocytose dying cells and cell debris, immune complexes, bacteria and other waste …

Tissue-resident alveolar and interstitial macrophages and recruited macrophages are critical
players in innate immunity and maintenance of lung homeostasis. Until recently, assessing …

Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

The extracellular matrix (ECM) is the complex meshwork of proteins and glycans that forms
the scaffold that surrounds and supports cells. It exerts key roles in all aspects of metazoan …

Blood vessel endothelial cells (ECs) have long been known to modulate inflammation by
regulating immune cell trafficking, activation status and function. However, whether the …

Single-cell transcriptomics has allowed unprecedented resolution of cell types/states in the
human lung, but their spatial context is less well defined. To (re) define tissue architecture of …

The accumulation of senescent cells in the tumor microenvironment can drive tumorigenesis
in a paracrine manner through the senescence-associated secretory phenotype (SASP) …

Ageing leads to profound alterations in the immune system and increases susceptibility to
some chronic, infectious and autoimmune diseases. In recent years, widespread application …

Primary tumors actively and specifically prime pre-metastatic niches (PMNs), the future sites
of organotropic metastasis, preparing these distant microenvironments for disseminated …

The lungs are constantly exposed to inhaled debris, allergens, pollutants, commensal or
pathogenic microorganisms, and respiratory viruses. As a result, innate and adaptive …