In eukaryotes, the genome does not exist as a linear molecule but instead is hierarchically
packaged inside the nucleus. This complex genome organization includes multiscale …

BACKGROUND Infertility is a major issue in human reproductive health, affecting an
estimated 15% of couples worldwide. Infertility can result from disorders of sex development …

In mammals, translational control plays critical roles during oocyte-to-embryo transition
(OET) when transcription ceases. However, the underlying regulatory mechanisms remain …

Full-grown oocytes are transcriptionally silent and must stably maintain the messenger
RNAs (mRNAs) needed for oocyte meiotic maturation and early embryonic development …

A remarkable epigenetic remodelling process occurs shortly after fertilization, which restores
totipotency to the zygote. This involves global DNA demethylation, chromatin remodelling …

The first major developmental transition in vertebrate embryos is the maternal-to-zygotic
transition (MZT) when maternal mRNAs are degraded and zygotic transcription begins …

YTHDF2 binds and destabilizes N 6-methyladenosine (m 6 A)-modified mRNA. The extent to
which this branch of m 6 A RNA-regulatory pathway functions in vivo and contributes to …

BACKGROUND In a growth phase occurring during most of folliculogenesis, the oocyte
produces and accumulates molecules and organelles that are fundamental for the …

Transcriptional control requires epigenetic changes directed by mitochondrial tricarboxylic
acid (TCA) cycle metabolites. In the mouse embryo, global epigenetic changes occur during …

Epigenetic modifications are crucial for the identity and stability of cells, and, when aberrant,
can lead to disease. During mouse development, the genome-wide epigenetic states of pre …