Unveiling the role of astrocytes in postoperative cognitive dysfunction

L He, X Duan, S Li, R Zhang, X Dai, M Lu - Ageing Research Reviews, 2024 - Elsevier
Alzheimer's disease (AD) is the most common neurodegenerative disorder, characterized by
progressive cognitive decline and the accumulation of amyloid-beta plaques, tau tangles …

[HTML][HTML] Research progress in Alzheimer's disease and bone-brain axis

F Zhang, W Zhang - Ageing Research Reviews, 2024 - Elsevier
Alzheimer's disease (AD) is the most common type of cognitive impairment. AD is closely
related to orthopedic diseases, such as osteoporosis and osteoarthritis, in terms of …

[HTML][HTML] Targeting Microglia in Alzheimer's Disease: Pathogenesis and Potential Therapeutic Strategies

Z Sun, X Zhang, KF So, W Jiang, K Chiu - Biomolecules, 2024 - mdpi.com
Microglia, as resident macrophages in the central nervous system, play a multifunctional role
in the pathogenesis of Alzheimer's disease (AD). Their clustering around amyloid-β (Aβ) …

Targeting chaperone-mediated autophagy in neurodegenerative diseases: mechanisms and therapeutic potential

J Wu, W Xu, Y Su, G Wang, J Ma - Acta pharmacologica Sinica, 2024 - nature.com
The pathological hallmarks of various neurodegenerative diseases including Parkinson's
disease and Alzheimer's disease prominently feature the accumulation of misfolded proteins …

The role of estrogen in Alzheimer's disease pathogenesis and therapeutic potential in women

X Wang, S Feng, Q Deng, C Wu, R Duan… - Molecular and Cellular …, 2024 - Springer
Estrogens are pivotal regulators of brain function throughout the lifespan, exerting profound
effects from early embryonic development to aging. Extensive experimental evidence …

Nanoligomers targeting NF-κB and NLRP3 reduce neuroinflammation and improve cognitive function with aging and tauopathy

D Wahl, SJ Risen, SC Osburn, T Emge… - Journal of …, 2024 - Springer
Neuroinflammation contributes to impaired cognitive function in brain aging and
neurodegenerative disorders like Alzheimer's disease, which is characterized by the …

[HTML][HTML] Alzheimer's disease, obesity, and type 2 diabetes: focus on common neuroglial dysfunctions (critical review and new data on human brain and models)

A Toledano, A Rodríguez-Casado, MI Älvarez… - Brain Sciences, 2024 - mdpi.com
Background/Objectives. Obesity, type 2 diabetes (T2D), and Alzheimer's disease (AD) are
pathologies that affect millions of people worldwide. They have no effective therapy and are …

Glycolytic dysregulation in Alzheimer's disease: Unveiling new avenues for understanding pathogenesis and improving therapy

Y Wu, L Yang, W Jiang, X Zhang… - Neural Regeneration …, 2025 - journals.lww.com
Alzheimer's disease poses a significant global health challenge owing to the progressive
cognitive decline of patients and absence of curative treatments. The current therapeutic …

Role of astrocytes in Alzheimer's disease pathogenesis and the impact of exercise-induced remodeling

J Shao, Q Deng, S Feng, C Wu, X Liu, L Yang - … and biophysical research …, 2024 - Elsevier
Alzheimer's disease (AD) is a prevalent and debilitating brain disorder that worsens
progressively with age, characterized by cognitive decline and memory impairment. The …

Gallic acid ameliorates LPS-induced memory decline by modulating NF-κB, TNF-α, and Caspase 3 gene expression and attenuating oxidative stress and neuronal …

M Dastan, Z Rajaei, M Sharifi, H Salehi - Metabolic Brain Disease, 2024 - Springer
Neuroinflammation and apoptosis play critical roles in the pathogenesis of Alzheimer's
disease (AD), which is responsible for most cases of dementia in the elderly people. Gallic …