Currently, obesity has become a global health issue and is referred to as an epidemic.
Dysfunctional obese adipose tissue plays a pivotal role in the development of insulin …

Lipopolysaccharides (LPSs) are bacterial surface glycolipids, produced by Gram-negative
bacteria. LPS is known to determine acute inflammatory reactions, particularly in the context …

The NLRP3 inflammasome is a multimeric protein complex that initiates an inflammatory
form of cell death and triggers the release of proinflammatory cytokines IL-1β and IL-18. The …

Background Pyroptosis is a new programmed cell death discovered in recent years.
Pyroptosis plays an important role in various diseases. Nevertheless, there are few …

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical …

Inflammasomes are inflammatory signaling complexes that provide molecular platforms to
activate the protease function of inflammatory caspases. Caspases-1,-4,-5, and-11 are …

Pyroptosis was long regarded as caspase-1-mediated monocyte death in response to
certain bacterial insults. Caspase-1 is activated upon various infectious and immunological …

Inflammatory caspases cleave the gasdermin D (GSDMD) protein to trigger pyroptosis, a
lytic form of cell death that is crucial for immune defences and diseases. GSDMD contains a …

Inflammasomes are macromolecular platforms formed in response to damage-associated
molecular patterns (DAMPs) and pathogen-associated molecular patterns, whose formation …

Abstract Inflammatory caspases (caspase-1,-4,-5 and-11) are critical for innate defences.
Caspase-1 is activated by ligands of various canonical inflammasomes, and caspase-4,-5 …