Long noncoding RNAs in development and cancer: potential biomarkers and therapeutic targets
Long noncoding RNAs are emerging as key players in various fundamental biological
processes. We highlight the varied molecular mechanisms by which lncRNAs modulate …
processes. We highlight the varied molecular mechanisms by which lncRNAs modulate …
Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance
Early-stage detection of leukemia is a critical determinant for successful treatment of the
disease and can increase the survival rate of leukemia patients. The factors limiting the …
disease and can increase the survival rate of leukemia patients. The factors limiting the …
LncRNAs H19 and HULC, activated by oxidative stress, promote cell migration and invasion in cholangiocarcinoma through a ceRNA manner
WT Wang, H Ye, PP Wei, BW Han, B He… - Journal of hematology & …, 2016 - Springer
Abstract Background Long non-coding RNAs (lncRNAs) are known to play important roles in
different cell contexts, including cancers. However, little is known about lncRNAs in …
different cell contexts, including cancers. However, little is known about lncRNAs in …
The lncRNA HOTAIRM1 regulates the degradation of PML-RARA oncoprotein and myeloid cell differentiation by enhancing the autophagy pathway
ZH Chen, WT Wang, W Huang, K Fang… - Cell Death & …, 2017 - nature.com
Increasing evidence has indicated that long noncoding RNAs (lncRNAs) are of great
importance in different cell contexts. However, only a very small number of lncRNAs have …
importance in different cell contexts. However, only a very small number of lncRNAs have …
LncRNA ANRIL regulates AML development through modulating the glucose metabolism pathway of AdipoR1/AMPK/SIRT1
The long noncoding RNA ANRIL has been found to be abnormally expressed and play
important roles in different cancers. However, the expression and function of ANRIL in acute …
important roles in different cancers. However, the expression and function of ANRIL in acute …
The lncRNA LAMP5-AS1 drives leukemia cell stemness by directly modulating DOT1L methyltransferase activity in MLL leukemia
WT Wang, TQ Chen, ZC Zeng, Q Pan, W Huang… - Journal of hematology & …, 2020 - Springer
Background Mixed-lineage leukemia (MLL) gene rearrangements trigger aberrant
epigenetic modification and gene expression in hematopoietic stem and progenitor cells …
epigenetic modification and gene expression in hematopoietic stem and progenitor cells …
LncRNA expression discriminates karyotype and predicts survival in B-lymphoblastic leukemia
TR Fernando, NI Rodriguez-Malave, EV Waters… - Molecular cancer …, 2015 - AACR
Long noncoding RNAs (lncRNA) have been found to play a role in gene regulation with
dysregulated expression in various cancers. The precise role that lncRNA expression plays …
dysregulated expression in various cancers. The precise role that lncRNA expression plays …
Long non-coding RNA and acute leukemia
Acute leukemia (AL) is the main type of cancer in children worldwide. Mortality by this
disease is high in develo** countries and its etiology remains unanswered. Evidences …
disease is high in develo** countries and its etiology remains unanswered. Evidences …
Diagnostic and therapeutic implications of long non-coding rnas in leukemia
Simple Summary Research on leukemia has often led to novel approaches in clinical
practice. Cytogenetical and molecular markers have been introduced in treatment protocols …
practice. Cytogenetical and molecular markers have been introduced in treatment protocols …
Long non-coding RNA signatures in Lymphopoiesis and lymphoid malignancies
Lymphoid cells play a critical role in the immune system, which includes three subgroups of
T, B, and NK cells. Recognition of the complexity of the human genetics transcriptome in …
T, B, and NK cells. Recognition of the complexity of the human genetics transcriptome in …