Precision medicine is a new frontier in healthcare that uses scientific methods to customize
medical treatment to the individual genes, anatomy, physiology, and lifestyle of each person …

The development and clinical use of patient-specific models of the heart is now a feasible
goal. Models have the potential to aid in diagnosis and support decision-making in clinical …

The heart is not only our most vital, but also our most complex organ: Precisely controlled by
the interplay of electrical and mechanical fields, it consists of four chambers and four valves …

We present a computational framework for multiscale modeling and simulation of blood flow
in coronary artery bypass graft (CABG) patients. Using this framework, only CT and non …

Patient-specific models of cardiac function have the potential to improve diagnosis and
management of heart disease by integrating medical images with heterogeneous clinical …

Background—To treat cardiac injuries created by myocardial infarcts, current approaches
seek to add cells and/or synthetic extracellular matrices to the damaged ventricle to restore …

In this study we present a novel, robust method to couple finite element (FE) models of
cardiac mechanics to systems models of the circulation (CIRC), independent of cardiac …

The pericardium affects cardiac motion by limiting epicardial displacement normal to the
surface. In computational studies, it is important for the model to replicate realistic motion, as …

Ventricular wall stress is believed to be responsible for many physical mechanisms taking
place in the human heart, including ventricular remodeling, which is frequently associated …

Background—The present study examined whether transplantation of adherent bone
marrow–derived stem cells, termed pMultistem, induces neovascularization and …