The transformative success of antibodies targeting the PD-1 (programmed death 1)/B7-H1
(B7 homolog 1) pathway (anti-PD therapy) has revolutionized cancer treatment. However …

Although immunotherapy research to date has focused largely on T cells, there is mounting
evidence that tumour-infiltrating B cells and plasma cells (collectively referred to as tumour …

An immunosuppressive tumour microenvironment is a major obstacle in the control of
pancreatic and other solid cancers,–. Agonists of the stimulator of interferon g enes (STING) …

The tumor microenvironment (TME) is a heterogeneous, complex organization composed of
tumor, stroma, and endothelial cells that is characterized by cross talk between tumor and …

Simple Summary The IL-12 family cytokines play an important role in regulating the tumor
immune contexture. Recent efforts geared towards the development of better immune …

Cytokines play a critical role in regulating host immune response toward cancer and
determining the overall fate of tumorigenesis. The tumor microenvironment is dominated …

Pancreatic ductal adenocarcinoma carries a dismal prognosis, and outcomes have
improved little with modern therapeutics. Checkpoint-based immunotherapy has failed to …

Tertiary lymphoid structures (TLSs) are defined as lymphoid aggregates formed in non-
hematopoietic organs under pathological conditions. Similar to secondary lymphoid organs …

Our understanding of tumor-infiltrating lymphocytes (TILs) is rapidly expanding beyond T cell-
centric perspectives to include B cells and plasma cells, collectively referred to as TIL-Bs. In …

Tumorigenesis proceeds through discrete steps where acquisition of genetic lesions and
changes in the surrounding microenvironment combine to drive unrestricted neoplastic …