The NLRP3 inflammasome is a multiprotein platform which is activated upon cellular
infection or stress. Its activation leads to caspase-1-dependent secretion of proinflammatory …

Atherosclerosis is a chronic inflammatory disorder characterized by the gradual buildup of
plaques within the vessel wall of middle-sized and large arteries. The occurrence and …

Human NLRP1 (NACHT, LRR, and PYD domain-containing protein 1) is an innate immune
sensor predominantly expressed in the skin and airway epithelium. Here, we report that …

Caspase-1 activated in inflammasomes triggers a programmed necrosis called pyroptosis,
which is mediated by gasdermin D (GSDMD). However, GSDMD-deficient cells are still …

Inflammasome complexes function as key innate immune effectors that trigger inflammation
in response to pathogen-and danger-associated signals. Here, we report that germline …

The extremely delicate shift from an inflammatory process to tumorigenesis is a field of major
scientific interest. While the inflammation induced by environmental agents has well known …

Innate immunity comprises several inflammation-related modulatory pathways which receive
signals from an array of membrane-bound and cytoplasmic pattern recognition receptors …

Trimethylamine N‐oxide (TMAO) is produced from the phosphatidylcholine metabolism of
gut flora and acts as a risk factor of cardiovascular disease. However, the underlying …

Cell death is an essential process that plays a vital role in restoring and maintaining skin
homeostasis. It supports recovery from acute injury and infection and regulates barrier …

Inflammasomes represent a group of protein complexes that contribute to host defense
against pathogens and repair processes upon the induction of inflammation. However …