Prevention, treatment and cure of HIV infection
The development of antiretroviral therapy for the prevention and treatment of HIV infection
has been marked by a series of remarkable successes. However, the efforts to develop a …
has been marked by a series of remarkable successes. However, the efforts to develop a …
Programming cytomegalovirus as an HIV vaccine
The initial development of cytomegalovirus (CMV) as a vaccine vector for HIV/simian
immunodeficiency virus (SIV) was predicated on its potential to pre-position high-frequency …
immunodeficiency virus (SIV) was predicated on its potential to pre-position high-frequency …
Combination anti-HIV antibodies provide sustained virological suppression
MC Sneller, J Blazkova, JS Justement, V Shi… - Nature, 2022 - nature.com
Antiretroviral therapy is highly effective in suppressing human immunodeficiency virus (HIV).
However, eradication of the virus in individuals with HIV has not been possible to date …
However, eradication of the virus in individuals with HIV has not been possible to date …
Distinct SIV-specific CD8+ T cells in the lymph node exhibit simultaneous effector and stem-like profiles and are associated with limited SIV persistence
Z Strongin, L Raymond Marchand, C Deleage… - Nature …, 2024 - nature.com
Human immunodeficiency virus (HIV) cure efforts are increasingly focused on harnessing
CD8+ T cell functions, which requires a deeper understanding of CD8+ T cells promoting …
CD8+ T cell functions, which requires a deeper understanding of CD8+ T cells promoting …
HIV post-treatment controllers have distinct immunological and virological features
HIV post-treatment controllers (PTCs) are rare individuals who maintain low levels of viremia
after stop** antiretroviral therapy (ART). Understanding the mechanisms of HIV post …
after stop** antiretroviral therapy (ART). Understanding the mechanisms of HIV post …
The HIV-1 reservoir landscape in persistent elite controllers and transient elite controllers
BACKGROUND Persistent controllers (PCs) maintain antiretroviral-free HIV-1 control
indefinitely over time, while transient controllers (TCs) eventually lose virological control. It is …
indefinitely over time, while transient controllers (TCs) eventually lose virological control. It is …
Cytolytic CD8+ T cells infiltrate germinal centers to limit ongoing HIV replication in spontaneous controller lymph nodes
DR Collins, J Hitschfel, JM Urbach… - Science …, 2023 - science.org
Follicular CD8+ T cells (fCD8) mediate surveillance in lymph node (LN) germinal centers
against lymphotropic infections and cancers, but the precise mechanisms by which these …
against lymphotropic infections and cancers, but the precise mechanisms by which these …
Modelling HIV-1 control and remission
Remarkable advances are being made in develo** interventions for eliciting long-term
remission of HIV-1 infection. The success of these interventions will obviate the need for …
remission of HIV-1 infection. The success of these interventions will obviate the need for …
Immune responses in controllers of HIV infection
AK Kwaa, JN Blankson - Annual review of immunology, 2024 - annualreviews.org
Elite controllers are a heterogeneous group of people living with HIV who control viral
replication without antiretroviral therapy. There is substantial evidence that at least some …
replication without antiretroviral therapy. There is substantial evidence that at least some …
Recent advances in poor HIV immune reconstitution: what will the future look like?
W Zhang, L Ruan - Frontiers in Microbiology, 2023 - frontiersin.org
Combination antiretroviral therapy has demonstrated proved effectiveness in suppressing
viral replication and significantly recovering CD4+ T cell count in HIV type-1 (HIV-1)-infected …
viral replication and significantly recovering CD4+ T cell count in HIV type-1 (HIV-1)-infected …