DNA origami has emerged as a powerful method to generate DNA nanostructures with
dynamic properties and nanoscale control. These nanostructures enable complex …

RNA modifications are emerging players in the field of post-transcriptional regulation of
gene expression, and are attracting a comparable degree of research interest to DNA and …

One of the most amazing findings in molecular biology was the discovery that eukaryotic
genes are discontinuous, with coding DNA being interrupted by stretches of non-coding …

Chemical modifications to nucleic acids occur across the kingdoms of life and carry
important regulatory information. Reliable high-resolution map** of these modifications is …

Many biological processes are RNA-mediated, but higher-order structures for most RNAs
are unknown, which makes it difficult to understand how RNA structure governs function …

Selective 2′-hydroxyl acylation analyzed by primer extension (SHAPE) chemistries exploit
small electrophilic reagents that react with 2′-hydroxyl groups to interrogate RNA structure …

A comprehensive understanding of RNA structure will provide fundamental insights into the
cellular function of both coding and non-coding RNAs. Although many RNA structures have …

Long noncoding RNAs (lncRNAs) have gained widespread attention in recent years as a
potentially new and crucial layer of biological regulation. lncRNAs of all kinds have been …

INTRODUCTION Many cellular RNAs contain regions that fold into stable structures required
for function. Both Watson− Crick and noncanonical interactions can play important roles in …

Nucleic acids have been among the first targets for antitumor drugs and antibiotics. With the
unveiling of new biological roles in regulation of gene expression, specific DNA and RNA …