N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels widely
expressed in the central nervous system that play key role in brain development and …

Peripheral and central sensitizations of the trigeminal nervous system are the main
mechanisms to promote the development and maintenance of chronic orofacial pain …

Shank3 is a synaptic scaffolding protein that assists in tethering and organizing structural
proteins and glutamatergic receptors in the postsynaptic density of excitatory synapses. The …

Stimulus-specific adaptation is a hallmark of sensory processing in which a repeated
stimulus results in diminished successive neuronal responses, but a deviant stimulus will …

Synaptic zinc is a neuromodulator that shapes synaptic transmission and sensory
processing. The maintenance of synaptic zinc is dependent on the vesicular zinc transporter …

Synaptic zinc ion (Zn2+) has emerged as a key neuromodulator in the brain. However, the
lack of research tools for directly tracking synaptic Zn2+ in the brain of awake animals …

Synaptic zinc signaling modulates synaptic activity and is present in specific populations of
cortical neurons, suggesting that synaptic zinc contributes to the diversity of intracortical …

Zinc (Zn) and copper (Cu) are essential for normal brain functions. In particular, Zn and Cu
are released to synaptic clefts during neuronal excitation. Synaptic Zn and Cu regulate …

Exposure to loud noise triggers sensory organ damage and degeneration that, in turn, leads
to hearing loss. Despite the troublesome impact of noise-induced hearing loss (NIHL) in …

Vesicular Zn2+ (zinc) is released at synapses and has been demonstrated to modulate
neuronal responses. However, mechanisms through which dysregulation of zinc …