Good practices for 68Ga radiopharmaceutical production

BJB Nelson, JD Andersson, F Wuest… - EJNMMI …, 2022 - Springer
Abstract Background The radiometal gallium-68 (68Ga) is increasingly used in diagnostic
positron emission tomography (PET), with 68Ga-labeled radiopharmaceuticals developed …

Production of radiometals in liquid targets

SJC do Carmo, PJH Scott, F Alves - EJNMMI Radiopharmacy and …, 2020 - Springer
Over the last several years, the use of radiometals has gained increasing relevance in
supporting the continuous development of new, complementary and more specific biological …

Cyclotron-based production of 68Ga, [68Ga]GaCl3, and [68Ga]Ga-PSMA-11 from a liquid target

ME Rodnick, C Sollert, D Stark, M Clark… - EJNMMI …, 2020 - Springer
Purpose To optimize the direct production of 68 Ga on a cyclotron, via the 68 Zn (p, n) 68 Ga
reaction using a liquid cyclotron target. We Investigated the yield of cyclotron-produced 68 …

The current status of the production and supply of gallium-68

K Kumar - Cancer biotherapy & radiopharmaceuticals, 2020 - liebertpub.com
Gallium-68 (68Ga) is an important radionuclide due to its successful use in the clinic.
Currently, 68Ga is produced and supplied by using germanium-68/Gallium-68 (68Ge/68Ga) …

Manganese in PET imaging: Opportunities and challenges

M Brandt, J Cardinale, I Rausch… - Journal of Labelled …, 2019 - Wiley Online Library
Several radionuclides of the transition metal manganese are known and accessible. Three
of them, 51Mn, 52mMn, and 52gMn, are positron emitters that are potentially interesting for …

Radiosynthesis of [18F]SiFAlin-TATE for clinical neuroendocrine tumor positron emission tomography

S Lindner, C Wängler, JJ Bailey, K Jurkschat… - Nature …, 2020 - nature.com
Here, we describe an extension of our silicon fluoride acceptor (SiFA) protocol for 18F-
labeling of peptides that addresses challenges associated with preparing a clinical-grade …

[HTML][HTML] A Theranostic Small-Molecule Prodrug Conjugate for Neuroendocrine Prostate Cancer

P Gonzalez, S Debnath, YA Chen, E Hernandez, P Jha… - Pharmaceutics, 2023 - mdpi.com
After androgen deprivation therapy, a significant number of prostate cancer cases progress
with a therapy-resistant neuroendocrine phenotype (NEPC). This represents a challenge for …

Cyclotron production of PET radiometals in liquid targets: aspects and prospects

MK Pandey, TR DeGrado - Current radiopharmaceuticals, 2021 - benthamdirect.com
The present review describes the methodological aspects and prospects of the production of
Positron Emission Tomography (PET) radiometals in a liquid target using low-medium …

Improved purification of cyclotron [68Ga] GaCl3 for the production of 68Ga radiopharmaceuticals

IE Wang, AF Brooks, M Clark, LJ Morrissette… - Nuclear Medicine and …, 2024 - Elsevier
Abstract Introduction Increased demand for NetSpot and Illuccix as requirement to receive
the respective Lutathera and Pluvicto radiotherapies, and monitor subsequent response to …

Rapid and automated production of [68Ga] gallium chloride and [68Ga] Ga-DOTA-TATE on a medical cyclotron

W Tieu, CA Hollis, KKW Kuan, P Takhar… - Nuclear Medicine and …, 2019 - Elsevier
Abstract Introduction The demand for Gallium-68 (68 Ga) for labelling PET
radiopharmaceuticals has increased over the past few years. 68 Ga is obtained through the …