The mammalian Rel/NF-κB family of transcription factors, including RelA, c-Rel, RelB, NF-
κB1 (p50 and its precursor p105), and NF-κB2 (p52 and its precursor p100), plays a central …

Abstract γδ T cells are a unique and conserved population of lymphocytes that have been
the subject of a recent explosion of interest owing to their essential contributions to many …

Psoriasis is a common, relapsing inflammatory skin disease characterized by erythematous
scaly plaques. Histological manifestations of psoriasis include keratinocyte dysregulation …

The production of cytokines such as interferon-γ and interleukin 17 by αβ and γδ T cells
influences the outcome of immune responses. Here we show that most γδ T lymphocytes …

The investigation of γδ T cells has identified a rapid lymphoid stress-surveillance response
to microbial and nonmicrobial tissue perturbation. In addition to providing local protection …

Multipotent blood progenitor cells enter the thymus and begin a protracted differentiation
process in which they gradually acquire T-cell characteristics while shedding their legacy of …

All hematopoietic cells, including T lymphocytes, originate from stem cells that reside in the
bone marrow. Most hematopoietic lineages also mature in the bone marrow, but in this …

The development of T cells in the thymus involves several differentiation and proliferation
events, during which hematopoietic precursors give rise to T cells ready to respond to …

γδ T cells are the first T cell lineage to develop in the thymus and take up residence in a
wide variety of tissues where they can provide fast, innate-like sources of effector cytokines …

The NF-κB signal transduction pathway is best known as a major regulator of innate and
adaptive immune responses, yet there is a growing appreciation of its importance in immune …