The ability to efficiently access cytosolic proteins is desired in both biological research and
medicine. However, targeting intracellular proteins is often challenging, because to reach …

Nucleic acids and their synthetic oligonucleotide (ON) analogs are a group of gene
therapeutic compounds which hold enormous clinical potential. Despite their undoubted …

The delivery of free molecules into the cytoplasm and nucleus by using arginine‐rich cell‐
penetrating peptides (CPPs) has been limited to small cargoes, while large cargoes such as …

Substrate-initiated, self-inactivating, cell-penetrating poly (disulfide) s (siCPDs) are
introduced as general transporters for the covalent delivery of unmodified substrates of free …

The objective of this Feature Article is to reflect on the importance of established and
emerging principles of supramolecular organic chemistry to address one of the most …

New preparation methods of vectors are the key to develo** the next generation of
biomacromolecule delivery systems. In this study, a controllable disulfide exchange …

Off-target effects of drugs severely limit cancer therapy. Targeted nanocarriers are promising
to enhance the delivery of therapeutics to tumors. Among many approaches for active tumor …

RNA interference (RNAi) with small interfering RNA (siRNA) is expected to offer an attractive
means to specifically and efficiently silence disease-associated genes for treating various …

Despite extensive use of arginine‐rich cell‐penetrating peptides (CPPs)—including
octaarginine (R8)—as intracellular delivery vectors, mechanisms for their internalization are …

Highlights•Peptides are a highly versatile class of promising drug candidates.•Peptides can
be both passively and actively cell permeable.•It is now possible to develop cell permeable …