Immune checkpoint inhibitors (ICIs) are monoclonal antibodies that target two key signalling
pathways related to T cell activation and exhaustion, by binding to and inhibiting cytotoxic T …

In the 1970s, treatment with thyroid extract was superseded by levothyroxine, a synthetic l
form of tetraiodothyronine. Since then, no major innovation has emerged for the treatment of …

Obesity is an emerging condition, with a prevalence of~ 20%. Although the simple
measurement of BMI is likely a simplistic approach to obesity, BMI is easily calculated, and …

Clinical hypothyroidism affects one in 300 people in the United States, with a higher
prevalence among female and older patients. Symptoms range from minimal to life …

Hypothyroidism is closely associated with increased serum total cholesterol (TC), low-
density lipoprotein cholesterol (LDL-C) and triglyceride (TG). The thyroid gland plays an …

Importance Subclinical hypothyroidism is a common clinical entity among US adults
associated in some studies with an increase in the risk of cardiovascular disease (CVD) and …

Context Hyperthyroidism is associated with low levels of cholesterol and triglycerides, and
hypothyroidism is associated with hypercholesterolemia and hypertriglyceridemia. Objective …

Hypothyroidism is the common clinical condition of thyroid hormone deficiency and, if left
untreated, can lead to serious adverse health effects on multiple organ systems, with the …

Common symptoms of overt hypothyroidism are non-specific and include fatigue, lethargy,
and dry skin. Although the diagnosis is considered to be straightforward, no single symptom …

Hypothyroidism is often associated with elevated serum levels of total cholesterol, low-
density lipoprotein cholesterol (LDL-C) and triglycerides. Thyroid hormone (TH) affects the …