An overview of the molecular mechanisms of recombinational DNA repair
SC Kowalczykowski - Cold Spring Harbor Perspectives …, 2015 - cshperspectives.cshlp.org
Recombinational DNA repair is a universal aspect of DNA metabolism and is essential for
genomic integrity. It is a template-directed process that uses a second chromosomal copy …
genomic integrity. It is a template-directed process that uses a second chromosomal copy …
Diverse functions of restriction-modification systems in addition to cellular defense
Restriction-modification (RM) systems are ubiquitous and are often considered primitive
immune systems in bacteria. Their diversity and prevalence across the prokaryotic kingdom …
immune systems in bacteria. Their diversity and prevalence across the prokaryotic kingdom …
Oxidative Stress Resistance in Deinococcus radiodurans
D Slade, M Radman - Microbiology and molecular biology reviews, 2011 - Am Soc Microbiol
Deinococcus radiodurans is a robust bacterium best known for its capacity to repair massive
DNA damage efficiently and accurately. It is extremely resistant to many DNA-damaging …
DNA damage efficiently and accurately. It is extremely resistant to many DNA-damaging …
DNA double-strand break repair: all's well that ends well
C Wyman, R Kanaar - Annu. Rev. Genet., 2006 - annualreviews.org
Breaks in both DNA strands are a particularly dangerous threat to genome stability. At a
DNA double-strand break (DSB), potentially lost sequence information cannot be recovered …
DNA double-strand break (DSB), potentially lost sequence information cannot be recovered …
End resection at double-strand breaks: mechanism and regulation
LS Symington - Cold Spring Harbor perspectives in …, 2014 - cshperspectives.cshlp.org
RecA/Rad51 catalyzed pairing of homologous DNA strands, initiated by polymerization of
the recombinase on single-stranded DNA (ssDNA), is a universal feature of homologous …
the recombinase on single-stranded DNA (ssDNA), is a universal feature of homologous …
RecBCD enzyme and the repair of double-stranded DNA breaks
SUMMARY The RecBCD enzyme of Escherichia coli is a helicase-nuclease that initiates the
repair of double-stranded DNA breaks by homologous recombination. It also degrades …
repair of double-stranded DNA breaks by homologous recombination. It also degrades …
DNA end resection: nucleases team up with the right partners to initiate homologous recombination
P Cejka - Journal of Biological Chemistry, 2015 - ASBMB
The repair of DNA double-strand breaks by homologous recombination commences by
nucleolytic degradation of the 5′-terminated strand of the DNA break. This leads to the …
nucleolytic degradation of the 5′-terminated strand of the DNA break. This leads to the …
Regulation of bacterial RecA protein function
MM Cox - Critical reviews in biochemistry and molecular biology, 2007 - Taylor & Francis
The RecA protein is a recombinase functioning in recombinational DNA repair in bacteria.
RecA is regulated at many levels. The expression of the recA gene is regulated within the …
RecA is regulated at many levels. The expression of the recA gene is regulated within the …
Crystal structure of RecBCD enzyme reveals a machine for processing DNA breaks
MR Singleton, MS Dillingham, M Gaudier… - Nature, 2004 - nature.com
RecBCD is a multi-functional enzyme complex that processes DNA ends resulting from a
double-strand break. RecBCD is a bipolar helicase that splits the duplex into its component …
double-strand break. RecBCD is a bipolar helicase that splits the duplex into its component …
Non-hexameric DNA helicases and translocases: mechanisms and regulation
Helicases and nucleic acid translocases are motor proteins that have essential roles in
nearly all aspects of nucleic acid metabolism, ranging from DNA replication to chromatin …
nearly all aspects of nucleic acid metabolism, ranging from DNA replication to chromatin …