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[HTML][HTML] Pleiotropic effects of statins: A focus on cancer
Abstract The statin drugs ('statins') potently inhibit hydroxymethylglutaryl-coenzyme A (HMG-
CoA) reductase by competitively blocking the active site of the enzyme. Statins decrease de …
CoA) reductase by competitively blocking the active site of the enzyme. Statins decrease de …
Statins and cancer: current and future prospects
M Osmak - Cancer letters, 2012 - Elsevier
Statins are inhibitors of 3-hydroxy-methylglutaryl (HMG) CoA reductase. They exhibit effects
beyond cholesterol reduction, including anticancer activity. This review presents the effects …
beyond cholesterol reduction, including anticancer activity. This review presents the effects …
Oxysterol-binding protein (OSBP)-related protein 4 (ORP4) is essential for cell proliferation and survival
M Charman, TR Colbourne, A Pietrangelo… - Journal of Biological …, 2014 - jbc.org
Oxysterol-binding protein (OSBP) and OSBP-related proteins (ORPs) comprise a large gene
family with sterol/lipid transport and regulatory activities. ORP4 (OSBP2) is a closely related …
family with sterol/lipid transport and regulatory activities. ORP4 (OSBP2) is a closely related …
[HTML][HTML] The Proteasome Inhibitor Marizomib Evokes Endoplasmic Reticulum Stress and Promotes Apoptosis in Human Glioblastoma Cells
M Kusaczuk, N Tyszka, R Krętowski… - Pharmaceuticals, 2024 - mdpi.com
Proteasomes play an important role in the physiology of cancer cells, and inhibition of their
activity may be used as a promising therapeutic strategy against glioblastoma (GBM) …
activity may be used as a promising therapeutic strategy against glioblastoma (GBM) …
[HTML][HTML] Rho GTPases: novel players in the regulation of the DNA damage response?
G Fritz, C Henninger - Biomolecules, 2015 - mdpi.com
The Ras-related C3 botulinum toxin substrate 1 (Rac1) belongs to the family of Ras-
homologous small GTPases. It is well characterized as a membrane-bound signal …
homologous small GTPases. It is well characterized as a membrane-bound signal …
XPC: Going where no DNA damage sensor has gone before
L Nemzow, A Lubin, L Zhang, F Gong - DNA repair, 2015 - Elsevier
XPC has long been considered instrumental in DNA damage recognition during global
genome nucleotide excision repair (GG-NER). While this recognition is crucial for …
genome nucleotide excision repair (GG-NER). While this recognition is crucial for …
Dexamethasone reduces sensitivity to cisplatin by blunting p53-dependent cellular senescence in non-small cell lung cancer
H Ge, S Ni, X Wang, N Xu, Y Liu, X Wang, L Wang… - PLoS …, 2012 - journals.plos.org
Introduction Dexamethasone (DEX) co-treatment has proved beneficial in NSCLC patients,
improving clinical symptoms by the reduction of side effects after chemotherapy. However …
improving clinical symptoms by the reduction of side effects after chemotherapy. However …
Overexpressed DNA polymerase iota regulated by JNK/c-Jun contributes to hypermutagenesis in bladder cancer
F Yuan, Z Xu, M Yang, Q Wei, Y Zhang, J Yu, Y Zhi… - PLoS …, 2013 - journals.plos.org
Human DNA polymerase iota (pol ι) possesses high error-prone DNA replication features
and performs translesion DNA synthesis. It may be specialized and strictly regulated in …
and performs translesion DNA synthesis. It may be specialized and strictly regulated in …
Enhanced phosphorylation of c-Jun by cisplatin treatment as a potential predictive biomarker for cisplatin response in combination with patient-derived tumor …
Y Tsukamoto, S Kurogi, T Shibata, K Suzuki… - Laboratory …, 2022 - nature.com
Despite recent advances in sequencing technology and large-scale drug screenings
employing hundreds of cell lines, the predictive accuracy of mutation-based biomarkers is …
employing hundreds of cell lines, the predictive accuracy of mutation-based biomarkers is …
[HTML][HTML] Platinum-induced kidney damage: Unraveling the DNA damage response (DDR) of renal tubular epithelial and glomerular endothelial cells following …
K Krüger, J Thomale, N Stojanović, M Osmak… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Background Platinum compounds are potent anticancer drugs but also evoke considerable
normal tissue damage. Here, we elucidate the molecular mechanisms contributing to the …
normal tissue damage. Here, we elucidate the molecular mechanisms contributing to the …