Plants and essential oils (EOs) have been used for centuries in folk medicine to treat diverse
disorders, including analgesic to pain relief. In this context, the antinociceptive activity of EOs …

The current translational crisis, in which apparently rapidly expanding genetic, molecular,
and cellular knowledge has not resulted in novel clinical therapies, has forced preclinical …

The rationale of this investigation was to examine the antinociceptive effect of an ethanol
extract of Rosmarinus officinalis (RO) aerial parts, using three different experimental models …

In response to concerns over the clinical relevance of analgesic testing paradigms which
involve acute nociceptive stimuli, the present research examined the utility of the …

The CatWalk automated quantitative gait analysis technique has been validated as a
method to quantify behaviour in rodent models of neuropathic and arthritic pain. Its suitability …

The rationale of this investigation was to examine the antinociceptive properties of the
essential oil obtained from Rosmarinus officinalis aerial parts, using a rat model of arthritic …

The rostral agranular insular cortex (RAIC) receives dopaminergic projections from the
mesolimbic system, which has been involved in the modulation of nociceptive processes. In …

It has been observed that some non-steroidal anti-inflammatory drugs (NSAIDs) may act
through several mechanisms, in addition to central inhibition of prostaglandin synthesis …

Tilia species are well known around the world for their properties in traditional medicine.
Antinociceptive activity of hexane, methanol and aqueous extracts from Tilia americana var …

The potential advantage of using combination therapy is that analgesia can be maximized
while minimizing the incidence of adverse effects. In order to assess a possible synergistic …