Transfer RNA (tRNA) is an adapter molecule that links a specific codon in mRNA with its
corresponding amino acid during protein synthesis. tRNAs are enzymatically modified post …

Oxidative stress, a term that describes the imbalance between oxidants and antioxidants,
leads to the disruption of redox signals and causes molecular damage. Increased oxidative …

Ageing is intimately connected to the induction of cell senescence,, but why this is so
remains poorly understood. A key challenge is the identification of pathways that normally …

Epitranscriptomic RNA modifications constitute a critical gene regulatory component that can
affect cancer progression. Among these, the RNA N4-acetylcytidine (ac4C) modification …

RNA modifications are dynamic and reversible chemical modifications on substrate RNA
that are regulated by specific modifying enzymes. They play important roles in the regulation …

Abstract Background N‐acetyltransferase 10 (NAT10) is the only enzyme known to mediate
the N4‐acetylcytidine (ac4C) modification of mRNA and is crucial for mRNA stability and …

As the most voluminous organ of the body that is exposed to the outer environment, the skin
suffers from both intrinsic and extrinsic aging factors. Skin aging is characterized by features …

Generation of the" epitranscriptome" through post-transcriptional ribonucleoside
modification embeds a layer of regulatory complexity into RNA structure and function. Here …

Abstract Background N4-acetylcytidine (ac4C) as a significant RNA modification has been
reported to maintain the stability of mRNA and to regulate the translation process. However …

The integrity of the nuclear envelope (NE) is essential for maintaining the structural stability
of the nucleus. Rupture of the NE has been frequently observed in cancer cells, especially in …